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Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

Inacio, Ana LU ; Liu, Yawei; Clausen, Bettina H; Svensson, Martina LU ; Kucharz, Krzysztof LU ; Yang, Yiyi LU ; Stankovich, Totte; Khorooshi, Reza; Lambertsen, Kate L and Issazadeh-Navikas, Shohreh, et al. (2015) In Journal of Neuroinflammation 12(1).
Abstract
Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.
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Journal of Neuroinflammation
volume
12
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26581581
  • wos:000364902200002
  • scopus:84960370618
ISSN
1742-2094
DOI
10.1186/s12974-015-0427-0
language
English
LU publication?
yes
id
ce6c86eb-b4e9-4880-b016-9701b7927404 (old id 8235218)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26581581?dopt=Abstract
date added to LUP
2015-12-05 18:25:36
date last changed
2017-10-01 04:11:38
@article{ce6c86eb-b4e9-4880-b016-9701b7927404,
  abstract     = {Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.},
  articleno    = {211},
  author       = {Inacio, Ana and Liu, Yawei and Clausen, Bettina H and Svensson, Martina and Kucharz, Krzysztof and Yang, Yiyi and Stankovich, Totte and Khorooshi, Reza and Lambertsen, Kate L and Issazadeh-Navikas, Shohreh and Deierborg, Tomas},
  issn         = {1742-2094},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Neuroinflammation},
  title        = {Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.},
  url          = {http://dx.doi.org/10.1186/s12974-015-0427-0},
  volume       = {12},
  year         = {2015},
}