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Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Goncharova, Katerina LU ; Ushakova, G.; Kovalenko, T.; Osadchenko, I.; Skibo, G. and Pierzynowski, Stefan LU (2015) In Journal of Functional Foods 14. p.270-277
Abstract
It is postulated that exocrine pancreatic insufficiency (EPI) can evoke neurological disorders. In the present study pancreatic-like enzymes of microbial origin (PLEM) were examined as a functional food component, with the goal of improving cognitive function and brain structure in a pig model of EPI. EPI in the present study induced alterations in the behaviour of the pigs as well as degenerative changes within the morphological structure of the hippocampus. EPI leads to a reduced number of pyramidal neurons and decreased levels of neural cell adhesion molecules (NCAM) in the CA1 area of the hippocampus. Here, we provide evidence that the use of PLEM as a functional food, in the form of dietary supplementation with PLEM for 10 days,... (More)
It is postulated that exocrine pancreatic insufficiency (EPI) can evoke neurological disorders. In the present study pancreatic-like enzymes of microbial origin (PLEM) were examined as a functional food component, with the goal of improving cognitive function and brain structure in a pig model of EPI. EPI in the present study induced alterations in the behaviour of the pigs as well as degenerative changes within the morphological structure of the hippocampus. EPI leads to a reduced number of pyramidal neurons and decreased levels of neural cell adhesion molecules (NCAM) in the CA1 area of the hippocampus. Here, we provide evidence that the use of PLEM as a functional food, in the form of dietary supplementation with PLEM for 10 days, restored pig behaviour and the histo-morphology of the hippocampus in EPI pigs. Thus, we suggest that the use of PLEM as a functional food ingredient should be considered in the prevention and/or postponement of the development of EPI-related encephalopathy. (C) 2015 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pigs, NCAM, Hippocampus, Exocrine pancreatic insufficiency, Behaviour
in
Journal of Functional Foods
volume
14
pages
270 - 277
publisher
Elsevier
external identifiers
  • wos:000364500000028
  • scopus:84926368155
ISSN
1756-4646
DOI
10.1016/j.jff.2015.01.014
language
English
LU publication?
yes
id
f7f299ab-4960-4640-b639-f2d476c06e85 (old id 8386407)
date added to LUP
2015-12-22 09:03:59
date last changed
2017-01-01 05:52:26
@article{f7f299ab-4960-4640-b639-f2d476c06e85,
  abstract     = {It is postulated that exocrine pancreatic insufficiency (EPI) can evoke neurological disorders. In the present study pancreatic-like enzymes of microbial origin (PLEM) were examined as a functional food component, with the goal of improving cognitive function and brain structure in a pig model of EPI. EPI in the present study induced alterations in the behaviour of the pigs as well as degenerative changes within the morphological structure of the hippocampus. EPI leads to a reduced number of pyramidal neurons and decreased levels of neural cell adhesion molecules (NCAM) in the CA1 area of the hippocampus. Here, we provide evidence that the use of PLEM as a functional food, in the form of dietary supplementation with PLEM for 10 days, restored pig behaviour and the histo-morphology of the hippocampus in EPI pigs. Thus, we suggest that the use of PLEM as a functional food ingredient should be considered in the prevention and/or postponement of the development of EPI-related encephalopathy. (C) 2015 Elsevier Ltd. All rights reserved.},
  author       = {Goncharova, Katerina and Ushakova, G. and Kovalenko, T. and Osadchenko, I. and Skibo, G. and Pierzynowski, Stefan},
  issn         = {1756-4646},
  keyword      = {Pigs,NCAM,Hippocampus,Exocrine pancreatic insufficiency,Behaviour},
  language     = {eng},
  pages        = {270--277},
  publisher    = {Elsevier},
  series       = {Journal of Functional Foods},
  title        = {Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency},
  url          = {http://dx.doi.org/10.1016/j.jff.2015.01.014},
  volume       = {14},
  year         = {2015},
}