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The analgesic effect of oxygen during percutaneous coronary intervention (the OXYPAIN Trial).

Sparv, David LU ; Bhiladvala, Pallonji LU ; Van Dijkman, Anna ; Harnek, Jan LU ; Madsen-Härdig, Bjarne LU ; Björk, Jonas LU ; Ekelund, Ulf LU orcid and Erlinge, David LU orcid (2013) In Acute Cardiac Care 15(3). p.63-68
Abstract
Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P... (More)
Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P = 0.12). The median difference in score of VAS was [95% CI]: 0, [0-1.0]. The oxygen group received 0.44 ± 0.11 mg of morphine versus 0.46 ± 0.13, P = n.s. The peak value of troponin-t post-PCI was 38, [11-352] nmol/ml in the oxygen group and 61, [16-241] for patients treated with air, P = 0.46. Conclusions: The use of oxygen during PCI did not demonstrate any analgesic effect. There was no difference in myocardial injury measured with troponin-t or in the morphine dose. Our results do not support routine use of oxygen. (NCT01413841.). (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acute Cardiac Care
volume
15
issue
3
pages
63 - 68
publisher
Taylor & Francis
external identifiers
  • pmid:23957447
  • scopus:84883033838
  • pmid:23957447
ISSN
1748-2941
DOI
10.3109/17482941.2013.822083
language
English
LU publication?
yes
id
84100a40-38c0-42d3-aa49-ba435398a579 (old id 4005537)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23957447?dopt=Abstract
date added to LUP
2016-04-01 10:51:59
date last changed
2024-01-07 02:57:12
@article{84100a40-38c0-42d3-aa49-ba435398a579,
  abstract     = {{Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P = 0.12). The median difference in score of VAS was [95% CI]: 0, [0-1.0]. The oxygen group received 0.44 ± 0.11 mg of morphine versus 0.46 ± 0.13, P = n.s. The peak value of troponin-t post-PCI was 38, [11-352] nmol/ml in the oxygen group and 61, [16-241] for patients treated with air, P = 0.46. Conclusions: The use of oxygen during PCI did not demonstrate any analgesic effect. There was no difference in myocardial injury measured with troponin-t or in the morphine dose. Our results do not support routine use of oxygen. (NCT01413841.).}},
  author       = {{Sparv, David and Bhiladvala, Pallonji and Van Dijkman, Anna and Harnek, Jan and Madsen-Härdig, Bjarne and Björk, Jonas and Ekelund, Ulf and Erlinge, David}},
  issn         = {{1748-2941}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{63--68}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acute Cardiac Care}},
  title        = {{The analgesic effect of oxygen during percutaneous coronary intervention (the OXYPAIN Trial).}},
  url          = {{https://lup.lub.lu.se/search/files/2197889/4402385.pdf}},
  doi          = {{10.3109/17482941.2013.822083}},
  volume       = {{15}},
  year         = {{2013}},
}