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Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats

Xu, Jie LU ; Lazou Ahrén, Irini LU ; Prykhodko, Olena LU ; Olsson, Crister LU ; Ahrné, Siv LU and Molin, Göran LU (2013) In Evidence-based Complementary and Alternative Medicine
Abstract
Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host. However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome. The N-G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement of Lactobacillus plantarum HEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermentation. The experimental diets did not lower the blood pressure after 4 weeks. However, the fermented blueberries together with live L. plantarum... (More)
Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host. However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome. The N-G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement of Lactobacillus plantarum HEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermentation. The experimental diets did not lower the blood pressure after 4 weeks. However, the fermented blueberries together with live L. plantarum showed protective effect on liver cells indicated by suppressed increase of serum alanine aminotransferase (ALAT) levels. The diversity of the caecal microbiota was neither affected by L-NAME nor the experimental diets. However, inhibition of the nitric oxide synthesis by L-NAME exerted a selection pressure that led to a shift in the bacterial composition. The mixture of fermented blueberries with the bacterial strain altered the caecal microbiota in different direction compared to L-NAME, while the three phenolic compounds together with the bacteria eliminated the selection pressure from the L-NAME. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Evidence-based Complementary and Alternative Medicine
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000317776800001
  • scopus:84877312307
ISSN
1741-427X
DOI
10.1155/2013/809128
language
English
LU publication?
yes
id
84513832-d4a8-474d-98fc-5848b6ba3af3 (old id 3857808)
date added to LUP
2013-06-19 13:22:25
date last changed
2018-09-09 03:07:40
@article{84513832-d4a8-474d-98fc-5848b6ba3af3,
  abstract     = {Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host. However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome. The N-G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement of Lactobacillus plantarum HEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermentation. The experimental diets did not lower the blood pressure after 4 weeks. However, the fermented blueberries together with live L. plantarum showed protective effect on liver cells indicated by suppressed increase of serum alanine aminotransferase (ALAT) levels. The diversity of the caecal microbiota was neither affected by L-NAME nor the experimental diets. However, inhibition of the nitric oxide synthesis by L-NAME exerted a selection pressure that led to a shift in the bacterial composition. The mixture of fermented blueberries with the bacterial strain altered the caecal microbiota in different direction compared to L-NAME, while the three phenolic compounds together with the bacteria eliminated the selection pressure from the L-NAME.},
  articleno    = {809128},
  author       = {Xu, Jie and Lazou Ahrén, Irini and Prykhodko, Olena and Olsson, Crister and Ahrné, Siv and Molin, Göran},
  issn         = {1741-427X},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Evidence-based Complementary and Alternative Medicine},
  title        = {Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats},
  url          = {http://dx.doi.org/10.1155/2013/809128},
  year         = {2013},
}