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Moraxella catarrhalis Evades Host Innate Immunity via Targeting Cartilage Oligomeric Matrix Protein.

Liu, Guanghui LU ; Gradstedt, Henrik LU ; Ermert, David LU ; Englund, Emelie LU ; Singh, Birendra LU ; Su, Yu-Ching LU ; Johansson, Martin LU ; Aspberg, Anders LU orcid ; Agarwal, Vaibhav LU and Riesbeck, Kristian LU orcid , et al. (2016) In Journal of Immunology 196(3). p.1249-1258
Abstract
Moraxella catarrhalis is a respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in patients suffering from chronic obstructive pulmonary disease. Cartilage oligomeric matrix protein (COMP) functions as a structural component in cartilage, as well as a regulator of complement activity. Importantly, COMP is detected in resident macrophages and monocytes, alveolar fluid, and the endothelium of blood vessels in lung tissue. We show that the majority of clinical isolates of M. catarrhalis (n = 49), but not other tested bacterial pathogens, bind large amounts of COMP. COMP interacts directly with the ubiquitous surface protein A2 of M. catarrhalis. Binding of COMP correlates with survival of M. catarrhalis... (More)
Moraxella catarrhalis is a respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in patients suffering from chronic obstructive pulmonary disease. Cartilage oligomeric matrix protein (COMP) functions as a structural component in cartilage, as well as a regulator of complement activity. Importantly, COMP is detected in resident macrophages and monocytes, alveolar fluid, and the endothelium of blood vessels in lung tissue. We show that the majority of clinical isolates of M. catarrhalis (n = 49), but not other tested bacterial pathogens, bind large amounts of COMP. COMP interacts directly with the ubiquitous surface protein A2 of M. catarrhalis. Binding of COMP correlates with survival of M. catarrhalis in human serum by inhibiting bactericidal activity of the complement membrane attack complex. Moreover, COMP inhibits phagocytic killing of M. catarrhalis by human neutrophils. We further observed that COMP reduces bacterial adhesion and uptake by human lung epithelial cells, thus protecting M. catarrhalis from intracellular killing by epithelial cells. Taken together, our findings uncover a novel mechanism that M. catarrhalis uses to evade host innate immunity. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
196
issue
3
pages
1249 - 1258
publisher
American Association of Immunologists
external identifiers
  • pmid:26712944
  • wos:000368596600032
  • scopus:84957707373
  • pmid:26712944
ISSN
1550-6606
DOI
10.4049/jimmunol.1502071
language
English
LU publication?
yes
id
65fd8491-9e31-41ad-a1b4-ff1a6de48ba4 (old id 8500256)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26712944?dopt=Abstract
date added to LUP
2016-04-01 09:53:20
date last changed
2025-04-04 15:11:48
@article{65fd8491-9e31-41ad-a1b4-ff1a6de48ba4,
  abstract     = {{Moraxella catarrhalis is a respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in patients suffering from chronic obstructive pulmonary disease. Cartilage oligomeric matrix protein (COMP) functions as a structural component in cartilage, as well as a regulator of complement activity. Importantly, COMP is detected in resident macrophages and monocytes, alveolar fluid, and the endothelium of blood vessels in lung tissue. We show that the majority of clinical isolates of M. catarrhalis (n = 49), but not other tested bacterial pathogens, bind large amounts of COMP. COMP interacts directly with the ubiquitous surface protein A2 of M. catarrhalis. Binding of COMP correlates with survival of M. catarrhalis in human serum by inhibiting bactericidal activity of the complement membrane attack complex. Moreover, COMP inhibits phagocytic killing of M. catarrhalis by human neutrophils. We further observed that COMP reduces bacterial adhesion and uptake by human lung epithelial cells, thus protecting M. catarrhalis from intracellular killing by epithelial cells. Taken together, our findings uncover a novel mechanism that M. catarrhalis uses to evade host innate immunity.}},
  author       = {{Liu, Guanghui and Gradstedt, Henrik and Ermert, David and Englund, Emelie and Singh, Birendra and Su, Yu-Ching and Johansson, Martin and Aspberg, Anders and Agarwal, Vaibhav and Riesbeck, Kristian and Blom, Anna}},
  issn         = {{1550-6606}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1249--1258}},
  publisher    = {{American Association of Immunologists}},
  series       = {{Journal of Immunology}},
  title        = {{Moraxella catarrhalis Evades Host Innate Immunity via Targeting Cartilage Oligomeric Matrix Protein.}},
  url          = {{http://dx.doi.org/10.4049/jimmunol.1502071}},
  doi          = {{10.4049/jimmunol.1502071}},
  volume       = {{196}},
  year         = {{2016}},
}