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Incidence of airflow limitation in subjects 65-100 years of age.

Luoto, Johannes LU ; Elmståhl, Sölve LU ; Wollmer, Per LU and Pihlsgård, Mats LU (2016) In European Respiratory Journal 47(2). p.461-472
Abstract
The true incidence of chronic obstructive pulmonary disease is largely unknown, because the few longitudinal studies performed have used diagnostic criteria no longer recommended by either the European Respiratory Society or the American Thoracic Society (ATS).We studied the incidence and significance of airflow limitation in a population-based geriatric sample using both an age-dependent predicted lower limit of normal (LLN) value and a fixed-ratio spirometric criterion.Out of 2025 subjects with acceptable spirometry at baseline, 984 subjects aged 65-100 years completed a 6-year follow-up visit. Smoking habits were registered at baseline. Exclusion criteria were non-acceptable spirometry performance according to ATS criteria and inability... (More)
The true incidence of chronic obstructive pulmonary disease is largely unknown, because the few longitudinal studies performed have used diagnostic criteria no longer recommended by either the European Respiratory Society or the American Thoracic Society (ATS).We studied the incidence and significance of airflow limitation in a population-based geriatric sample using both an age-dependent predicted lower limit of normal (LLN) value and a fixed-ratio spirometric criterion.Out of 2025 subjects with acceptable spirometry at baseline, 984 subjects aged 65-100 years completed a 6-year follow-up visit. Smoking habits were registered at baseline. Exclusion criteria were non-acceptable spirometry performance according to ATS criteria and inability to communicate. Airflow limitation was defined both according to forced expiratory volume in 1 s (FEV1)/forced vital capacity ratio <0.7 and <LLN.The incidence of airflow limitation per 1000 person-years was 28.2 using a fixed ratio and 11.7 with LLN, corresponding to a 1.41-fold higher incidence rate using a fixed ratio. The incidence increased dramatically with age when using a fixed ratio, but less so when using LLN. In addition, a sex effect was observed with the LLN criterion. LLN airflow limitation was associated with increased 5-year mortality. Presence of fixed-ratio airflow limitation in individuals classified by LLN as non-obstructive was not associated with increased mortality. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Respiratory Journal
volume
47
issue
2
pages
461 - 472
publisher
Eur Respiratory Soc
external identifiers
  • pmid:26677939
  • scopus:84958087450
  • wos:000385286600017
ISSN
1399-3003
DOI
10.1183/13993003.00635-2015
language
English
LU publication?
yes
id
14648407-df82-4da7-b16e-e63017fffa9b (old id 8504425)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26677939?dopt=Abstract
date added to LUP
2016-01-05 20:43:30
date last changed
2017-11-05 04:42:12
@article{14648407-df82-4da7-b16e-e63017fffa9b,
  abstract     = {The true incidence of chronic obstructive pulmonary disease is largely unknown, because the few longitudinal studies performed have used diagnostic criteria no longer recommended by either the European Respiratory Society or the American Thoracic Society (ATS).We studied the incidence and significance of airflow limitation in a population-based geriatric sample using both an age-dependent predicted lower limit of normal (LLN) value and a fixed-ratio spirometric criterion.Out of 2025 subjects with acceptable spirometry at baseline, 984 subjects aged 65-100 years completed a 6-year follow-up visit. Smoking habits were registered at baseline. Exclusion criteria were non-acceptable spirometry performance according to ATS criteria and inability to communicate. Airflow limitation was defined both according to forced expiratory volume in 1 s (FEV1)/forced vital capacity ratio &lt;0.7 and &lt;LLN.The incidence of airflow limitation per 1000 person-years was 28.2 using a fixed ratio and 11.7 with LLN, corresponding to a 1.41-fold higher incidence rate using a fixed ratio. The incidence increased dramatically with age when using a fixed ratio, but less so when using LLN. In addition, a sex effect was observed with the LLN criterion. LLN airflow limitation was associated with increased 5-year mortality. Presence of fixed-ratio airflow limitation in individuals classified by LLN as non-obstructive was not associated with increased mortality.},
  author       = {Luoto, Johannes and Elmståhl, Sölve and Wollmer, Per and Pihlsgård, Mats},
  issn         = {1399-3003},
  language     = {eng},
  number       = {2},
  pages        = {461--472},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Incidence of airflow limitation in subjects 65-100 years of age.},
  url          = {http://dx.doi.org/10.1183/13993003.00635-2015},
  volume       = {47},
  year         = {2016},
}