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A prebiotic oligofructose-enriched inulin preparation stimulates intestinal growth and function in suckling rats

Fåk, Frida LU orcid ; Johansson, Elin LU ; Ahrné, Siv LU ; Molin, Göran LU and Weström, Björn LU (2011) In International Journal of Probiotics and Prebiotics 6(1). p.49-56
Abstract

Postnatal development of the gastrointestinal (GI) tract in mammals is influenced, to an unknown extent, by the diet and the microflora. The aim of the current study was to clarify the role of a dietary fibre on postnatal Gl development, by studying the effects of aprebiotic oligofructose-enriched inulin preparation (Synergy 1) on GI growth and function in a suckling rat modcl Between 10 and 16 days of age, pups were daily gavaged with Synergy 1 (2.0 mglg b. wt), or Synergy 1 together with theprobiotic bacterium Lactobacillus plantarum 299v (Lp299v, 5.0 × 106 CFU/g b. wt), while control pups only received tap water. At 17 days of age, the prebiotic-treated pups showed an increased growth of the small intestine, along with increased... (More)

Postnatal development of the gastrointestinal (GI) tract in mammals is influenced, to an unknown extent, by the diet and the microflora. The aim of the current study was to clarify the role of a dietary fibre on postnatal Gl development, by studying the effects of aprebiotic oligofructose-enriched inulin preparation (Synergy 1) on GI growth and function in a suckling rat modcl Between 10 and 16 days of age, pups were daily gavaged with Synergy 1 (2.0 mglg b. wt), or Synergy 1 together with theprobiotic bacterium Lactobacillus plantarum 299v (Lp299v, 5.0 × 106 CFU/g b. wt), while control pups only received tap water. At 17 days of age, the prebiotic-treated pups showed an increased growth of the small intestine, along with increased mucosal lactase activity as compared to controls. Furthermore, prebiotic-treated pups had an increased proportion of mature (adult-type non-vacuolated) enterocytes in the distal small intestine as compared to the control pups. In the synbiotic group, the addition of Lp299v did not appear to enhance the effect of Synergy 1. The prebiotic oligofructose-enriched inulin preparation had a stimulatory effect on intestinal growth and maturation in young developing rats, probably through changes in SFCA concentrations or bacterial composition.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Intestine, Postnatal, Prebiotic, Rat, Vacuoles
in
International Journal of Probiotics and Prebiotics
volume
6
issue
1
pages
8 pages
publisher
New Century Health Publishers
external identifiers
  • scopus:84885658079
ISSN
1555-1431
language
English
LU publication?
yes
id
85520137-f061-4d43-abe0-930e021a979e
date added to LUP
2024-12-05 12:50:52
date last changed
2025-04-04 15:23:34
@article{85520137-f061-4d43-abe0-930e021a979e,
  abstract     = {{<p>Postnatal development of the gastrointestinal (GI) tract in mammals is influenced, to an unknown extent, by the diet and the microflora. The aim of the current study was to clarify the role of a dietary fibre on postnatal Gl development, by studying the effects of aprebiotic oligofructose-enriched inulin preparation (Synergy 1) on GI growth and function in a suckling rat modcl Between 10 and 16 days of age, pups were daily gavaged with Synergy 1 (2.0 mglg b. wt), or Synergy 1 together with theprobiotic bacterium Lactobacillus plantarum 299v (Lp299v, 5.0 × 106 CFU/g b. wt), while control pups only received tap water. At 17 days of age, the prebiotic-treated pups showed an increased growth of the small intestine, along with increased mucosal lactase activity as compared to controls. Furthermore, prebiotic-treated pups had an increased proportion of mature (adult-type non-vacuolated) enterocytes in the distal small intestine as compared to the control pups. In the synbiotic group, the addition of Lp299v did not appear to enhance the effect of Synergy 1. The prebiotic oligofructose-enriched inulin preparation had a stimulatory effect on intestinal growth and maturation in young developing rats, probably through changes in SFCA concentrations or bacterial composition.</p>}},
  author       = {{Fåk, Frida and Johansson, Elin and Ahrné, Siv and Molin, Göran and Weström, Björn}},
  issn         = {{1555-1431}},
  keywords     = {{Intestine; Postnatal; Prebiotic; Rat; Vacuoles}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{49--56}},
  publisher    = {{New Century Health Publishers}},
  series       = {{International Journal of Probiotics and Prebiotics}},
  title        = {{A prebiotic oligofructose-enriched inulin preparation stimulates intestinal growth and function in suckling rats}},
  volume       = {{6}},
  year         = {{2011}},
}