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18 F-Flortaucipir in TDP-43 associated frontotemporal dementia

Smith, R. LU ; Santillo, A. F. LU ; Waldö, M. Landqvist LU ; Strandberg, O. LU ; Berron, D. LU ; Vestberg, S. LU ; van Westen, D. LU ; van Swieten, J.; Honer, M. and Hansson, O. LU (2019) In Scientific Reports 9(1).
Abstract


Retention of
18
F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if
18
F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent ... (More)


Retention of
18
F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if
18
F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent
18
F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using
3
H-Flortaucipir was performed. SvPPA patients exhibited higher
18
F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients,
18
F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe
18
F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited
18
F-Flortaucipir retention, indicating that
18
F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
9
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85064457963
ISSN
2045-2322
DOI
10.1038/s41598-019-42625-9
language
English
LU publication?
yes
id
855a6f2d-c625-422b-8c3d-7141ef1ed91e
date added to LUP
2019-05-02 13:15:52
date last changed
2019-10-21 02:17:59
@article{855a6f2d-c625-422b-8c3d-7141ef1ed91e,
  abstract     = {<p><br>
                                                         Retention of                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using                              <br>
                            <sup>3</sup><br>
                                                         H-Flortaucipir was performed. SvPPA patients exhibited higher                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients,                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir retention, indicating that                              <br>
                            <sup>18</sup><br>
                                                         F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.                         <br>
                        </p>},
  articleno    = {6082},
  author       = {Smith, R. and Santillo, A. F. and Waldö, M. Landqvist and Strandberg, O. and Berron, D. and Vestberg, S. and van Westen, D. and van Swieten, J. and Honer, M. and Hansson, O.},
  issn         = {2045-2322},
  language     = {eng},
  month        = {04},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {<sup>18</sup>
                                                 F-Flortaucipir in TDP-43 associated frontotemporal dementia},
  url          = {http://dx.doi.org/10.1038/s41598-019-42625-9},
  volume       = {9},
  year         = {2019},
}