18 F-Flortaucipir in TDP-43 associated frontotemporal dementia
Smith, R. LU ; Santillo, A. F. LU
; Waldö, M. Landqvist
LU
; Strandberg, O.
LU
; Berron, D.
LU
; Vestberg, S.
LU
; van Westen, D.
LU
; van Swieten, J.
; Honer, M.
and Hansson, O.
LU
(2019)
In Scientific Reports
9(1).
- Abstract
Retention of
18
F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if
18
F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent ... (More)
(Less)
Retention of
18
F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if
18
F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent
18
F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using
3
H-Flortaucipir was performed. SvPPA patients exhibited higher
18
F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients,
18
F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe
18
F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited
18
F-Flortaucipir retention, indicating that
18
F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.
- author
- Smith, R.
LU
; Santillo, A. F.
LU
; Waldö, M. Landqvist
LU
; Strandberg, O.
LU
; Berron, D.
LU
; Vestberg, S.
LU
; van Westen, D.
LU
; van Swieten, J.
; Honer, M.
and Hansson, O.
LU
- organization
- publishing date
- 2019-04-15
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 9
- issue
- 1
- article number
- 6082
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85064457963
- pmid:30988363
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-019-42625-9
- language
- English
- LU publication?
- yes
- id
- 855a6f2d-c625-422b-8c3d-7141ef1ed91e
- date added to LUP
- 2019-05-02 13:15:52
- date last changed
- 2024-03-19 05:42:41
@article{855a6f2d-c625-422b-8c3d-7141ef1ed91e,
abstract = {{<p><br>
Retention of <br>
<sup>18</sup><br>
F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if <br>
<sup>18</sup><br>
F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent <br>
<sup>18</sup><br>
F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using <br>
<sup>3</sup><br>
H-Flortaucipir was performed. SvPPA patients exhibited higher <br>
<sup>18</sup><br>
F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients, <br>
<sup>18</sup><br>
F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe <br>
<sup>18</sup><br>
F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited <br>
<sup>18</sup><br>
F-Flortaucipir retention, indicating that <br>
<sup>18</sup><br>
F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon. <br>
</p>}},
author = {{Smith, R. and Santillo, A. F. and Waldö, M. Landqvist and Strandberg, O. and Berron, D. and Vestberg, S. and van Westen, D. and van Swieten, J. and Honer, M. and Hansson, O.}},
issn = {{2045-2322}},
language = {{eng}},
month = {{04}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{<sup>18</sup>
F-Flortaucipir in TDP-43 associated frontotemporal dementia}},
url = {{http://dx.doi.org/10.1038/s41598-019-42625-9}},
doi = {{10.1038/s41598-019-42625-9}},
volume = {{9}},
year = {{2019}},
}