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Walking by design : how to build artificial molecular motors made of proteins

Nilsson, Patrik F. LU ; Zink, Anna ; Laprévote, Olivier M.C. ; Korosec, Chapin S. ; Gustafsson, Nils LU ; Robertson, Neil O. ; Forde, Nancy R. ; Eichhorn, Ralf ; Höcker, Birte and Curmi, Paul M.G. , et al. (2024) In Nano Futures 8(4).
Abstract

To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecular motors, nanotechnology, protein design, proteins, synthetic biology
in
Nano Futures
volume
8
issue
4
article number
042501
publisher
IOP Publishing
external identifiers
  • scopus:85206882043
ISSN
2399-1984
DOI
10.1088/2399-1984/ad7d7e
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Author(s). Published by IOP Publishing Ltd.
id
85648734-4591-4a6e-aad7-f83277087366
date added to LUP
2024-11-26 10:56:02
date last changed
2025-04-04 14:41:02
@article{85648734-4591-4a6e-aad7-f83277087366,
  abstract     = {{<p>To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.</p>}},
  author       = {{Nilsson, Patrik F. and Zink, Anna and Laprévote, Olivier M.C. and Korosec, Chapin S. and Gustafsson, Nils and Robertson, Neil O. and Forde, Nancy R. and Eichhorn, Ralf and Höcker, Birte and Curmi, Paul M.G. and Linke, Heiner}},
  issn         = {{2399-1984}},
  keywords     = {{molecular motors; nanotechnology; protein design; proteins; synthetic biology}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{4}},
  publisher    = {{IOP Publishing}},
  series       = {{Nano Futures}},
  title        = {{Walking by design : how to build artificial molecular motors made of proteins}},
  url          = {{http://dx.doi.org/10.1088/2399-1984/ad7d7e}},
  doi          = {{10.1088/2399-1984/ad7d7e}},
  volume       = {{8}},
  year         = {{2024}},
}