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Mitochondrial function in peripheral blood cells across the human lifespan

Ehinger, Johannes K. LU orcid ; Westerlund, Emil LU orcid ; Frostner, Eleonor Åsander LU orcid ; Karlsson, Michael ; Paul, Gesine LU ; Sjövall, Fredrik LU orcid and Elmér, Eskil LU orcid (2024) In npj Aging 10(1).
Abstract

Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in... (More)

Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Aging
volume
10
issue
1
article number
10
publisher
Springer Nature
external identifiers
  • pmid:38326348
  • scopus:85184924260
ISSN
2731-6068
DOI
10.1038/s41514-023-00130-4
project
Mitochondrial function in human aging
language
English
LU publication?
yes
id
8773f9bd-6936-4ae9-a806-1a4f3a33df32
date added to LUP
2024-02-26 14:21:40
date last changed
2024-04-25 22:34:29
@article{8773f9bd-6936-4ae9-a806-1a4f3a33df32,
  abstract     = {{<p>Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.</p>}},
  author       = {{Ehinger, Johannes K. and Westerlund, Emil and Frostner, Eleonor Åsander and Karlsson, Michael and Paul, Gesine and Sjövall, Fredrik and Elmér, Eskil}},
  issn         = {{2731-6068}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Springer Nature}},
  series       = {{npj Aging}},
  title        = {{Mitochondrial function in peripheral blood cells across the human lifespan}},
  url          = {{http://dx.doi.org/10.1038/s41514-023-00130-4}},
  doi          = {{10.1038/s41514-023-00130-4}},
  volume       = {{10}},
  year         = {{2024}},
}