Mitochondrial function in peripheral blood cells across the human lifespan
(2024) In npj Aging 10(1).- Abstract
Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in... (More)
Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.
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- author
- Ehinger, Johannes K. LU ; Westerlund, Emil LU ; Frostner, Eleonor Åsander LU ; Karlsson, Michael ; Paul, Gesine LU ; Sjövall, Fredrik LU and Elmér, Eskil LU
- organization
-
- Mitochondrial Medicine (research group)
- LU Profile Area: Proactive Ageing
- Otorhinolaryngology (Lund)
- Clinical Neurophysiology
- WCMM-Wallenberg Centre for Molecular Medicine
- Regeneration in Movement Disorders (research group)
- Translational Neurology (TNY) (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Neurology, Lund
- Anesthesiology and Intensive Care
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- npj Aging
- volume
- 10
- issue
- 1
- article number
- 10
- publisher
- Springer Nature
- external identifiers
-
- pmid:38326348
- scopus:85184924260
- ISSN
- 2731-6068
- DOI
- 10.1038/s41514-023-00130-4
- project
- Mitochondrial function in human aging
- language
- English
- LU publication?
- yes
- id
- 8773f9bd-6936-4ae9-a806-1a4f3a33df32
- date added to LUP
- 2024-02-26 14:21:40
- date last changed
- 2024-04-25 22:34:29
@article{8773f9bd-6936-4ae9-a806-1a4f3a33df32, abstract = {{<p>Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0–86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.</p>}}, author = {{Ehinger, Johannes K. and Westerlund, Emil and Frostner, Eleonor Åsander and Karlsson, Michael and Paul, Gesine and Sjövall, Fredrik and Elmér, Eskil}}, issn = {{2731-6068}}, language = {{eng}}, number = {{1}}, publisher = {{Springer Nature}}, series = {{npj Aging}}, title = {{Mitochondrial function in peripheral blood cells across the human lifespan}}, url = {{http://dx.doi.org/10.1038/s41514-023-00130-4}}, doi = {{10.1038/s41514-023-00130-4}}, volume = {{10}}, year = {{2024}}, }