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Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Iversen, AKN; Christiansen, CB; Attermann, J; Eugen-Olsen, J; Schulman, S; Berntorp, Erik LU ; Ingerslev, J; Fugger, L; Scheibel, E and Tengborn, Lilian LU , et al. (2003) In Journal of Infectious Diseases 187(2). p.215-225
Abstract
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was... (More)
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors. (Less)
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Journal of Infectious Diseases
volume
187
issue
2
pages
215 - 225
publisher
Oxford University Press
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  • pmid:12552446
  • wos:000180226500006
ISSN
1537-6613
language
English
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yes
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9d2f9bbe-6e90-4c6d-9e8a-51349acf6004 (old id 892092)
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http://ucp.uchicago.edu/JID/journal/issues/v187n2/020881/brief/020881.abstract.html
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2008-01-14 13:57:55
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@article{9d2f9bbe-6e90-4c6d-9e8a-51349acf6004,
  abstract     = {The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.},
  author       = {Iversen, AKN and Christiansen, CB and Attermann, J and Eugen-Olsen, J and Schulman, S and Berntorp, Erik and Ingerslev, J and Fugger, L and Scheibel, E and Tengborn, Lilian and Gerstoft, J and Dickmeiss, E and Svejgaard, A and Skinhoj, P},
  issn         = {1537-6613},
  language     = {eng},
  number       = {2},
  pages        = {215--225},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus},
  volume       = {187},
  year         = {2003},
}