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Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017

Norén, Erika LU ; Lindh, Christian LU orcid ; Rylander, Lars LU orcid ; Glynn, Anders ; Axelsson, Jonatan LU ; Littorin, Margareta LU ; Faniband, Moosa LU ; Larsson, Estelle LU orcid and Nielsen, Christel LU orcid (2020) In Journal of Exposure Science and Environmental Epidemiology 30(4). p.756-767
Abstract

Agricultural pesticides are extensively used for weed- and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC–MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC),... (More)

Agricultural pesticides are extensively used for weed- and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC–MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC), thiabendazole (OH-TBZ), and mancozeb (ETU) were detected in >90% of the population all sampling years. The biomarkers CCC and TCPy had the highest median concentrations (>0.8 µg/L), whereas the biomarkers of cyfluthrin (4F-3-PBA) and two pyrethroids (CFCA) had the lowest median concentrations (<0.02 µg/L). Increasing temporal trends were found for the biomarkers 3-PBA (3.7%/year), TCPy (1.7%/year) and biomarkers of pyrimethanil (11.9%/year) and tebuconazole (12.2%/year). Decreasing trends were found for CCC (–5.5%/year), OH-TBZ (−5.5%/year), and ETU (−3.9%/year). Our results suggest that Swedish adolescents are commonly exposed to pesticides in low concentrations (median concentrations <3.88 µg/L).

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomonitoring, Dietary exposure, Pesticides, Population based studies
in
Journal of Exposure Science and Environmental Epidemiology
volume
30
issue
4
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85079376320
  • pmid:32094458
ISSN
1559-0631
DOI
10.1038/s41370-020-0212-8
language
English
LU publication?
yes
id
8a60f002-78c5-4b31-a6e6-a5de8ea71f24
date added to LUP
2020-07-11 10:46:46
date last changed
2024-04-17 12:37:38
@article{8a60f002-78c5-4b31-a6e6-a5de8ea71f24,
  abstract     = {{<p>Agricultural pesticides are extensively used for weed- and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC–MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC), thiabendazole (OH-TBZ), and mancozeb (ETU) were detected in &gt;90% of the population all sampling years. The biomarkers CCC and TCPy had the highest median concentrations (&gt;0.8 µg/L), whereas the biomarkers of cyfluthrin (4F-3-PBA) and two pyrethroids (CFCA) had the lowest median concentrations (&lt;0.02 µg/L). Increasing temporal trends were found for the biomarkers 3-PBA (3.7%/year), TCPy (1.7%/year) and biomarkers of pyrimethanil (11.9%/year) and tebuconazole (12.2%/year). Decreasing trends were found for CCC (–5.5%/year), OH-TBZ (−5.5%/year), and ETU (−3.9%/year). Our results suggest that Swedish adolescents are commonly exposed to pesticides in low concentrations (median concentrations &lt;3.88 µg/L).</p>}},
  author       = {{Norén, Erika and Lindh, Christian and Rylander, Lars and Glynn, Anders and Axelsson, Jonatan and Littorin, Margareta and Faniband, Moosa and Larsson, Estelle and Nielsen, Christel}},
  issn         = {{1559-0631}},
  keywords     = {{Biomonitoring; Dietary exposure; Pesticides; Population based studies}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{4}},
  pages        = {{756--767}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Exposure Science and Environmental Epidemiology}},
  title        = {{Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017}},
  url          = {{http://dx.doi.org/10.1038/s41370-020-0212-8}},
  doi          = {{10.1038/s41370-020-0212-8}},
  volume       = {{30}},
  year         = {{2020}},
}