Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
(2010) In Experimental Neurology 223. p.653-656- Abstract
- The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1553062
- author
- Tønnesen, Jan ; Seiz, Emma Gonzalez ; Ramos, Milagros ; Lindvall, Olle LU ; Martinez-Serrano, Alberto and Kokaia, Merab LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Neurology
- volume
- 223
- pages
- 653 - 656
- publisher
- Elsevier
- external identifiers
-
- wos:000277743700046
- pmid:20122925
- scopus:77952554364
- pmid:20122925
- ISSN
- 0014-4886
- DOI
- 10.1016/j.expneurol.2010.01.013
- language
- English
- LU publication?
- yes
- id
- 8b53ad3b-0fee-4bed-b68f-42e1b3eb6206 (old id 1553062)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20122925?dopt=Abstract
- date added to LUP
- 2016-04-04 07:08:49
- date last changed
- 2022-01-29 01:49:34
@article{8b53ad3b-0fee-4bed-b68f-42e1b3eb6206,
abstract = {{The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions.}},
author = {{Tønnesen, Jan and Seiz, Emma Gonzalez and Ramos, Milagros and Lindvall, Olle and Martinez-Serrano, Alberto and Kokaia, Merab}},
issn = {{0014-4886}},
language = {{eng}},
pages = {{653--656}},
publisher = {{Elsevier}},
series = {{Experimental Neurology}},
title = {{Functional properties of the human ventral mesencephalic neural stem cell line hVM1.}},
url = {{http://dx.doi.org/10.1016/j.expneurol.2010.01.013}},
doi = {{10.1016/j.expneurol.2010.01.013}},
volume = {{223}},
year = {{2010}},
}