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Metabolite profiling of LADA challenges the view of a metabolically distinct subtype

Al-Majdoub, Mahmoud LU ; Ali, Arslan; Storm, Petter LU ; Rosengren, Anders H. LU ; Groop, Leif LU and Spégel, Peter LU (2017) In Diabetes 66(4). p.806-814
Abstract

Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2... (More)

Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
66
issue
4
pages
9 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85019567445
  • wos:000397114900005
ISSN
0012-1797
DOI
10.2337/db16-0779
language
English
LU publication?
yes
id
8bff9d7f-8842-4c0a-b558-e28eb5f9351c
date added to LUP
2017-07-03 17:54:23
date last changed
2017-09-18 11:37:25
@article{8bff9d7f-8842-4c0a-b558-e28eb5f9351c,
  abstract     = {<p>Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.</p>},
  author       = {Al-Majdoub, Mahmoud and Ali, Arslan and Storm, Petter and Rosengren, Anders H. and Groop, Leif and Spégel, Peter},
  issn         = {0012-1797},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {806--814},
  publisher    = {American Diabetes Association},
  series       = {Diabetes},
  title        = {Metabolite profiling of LADA challenges the view of a metabolically distinct subtype},
  url          = {http://dx.doi.org/10.2337/db16-0779},
  volume       = {66},
  year         = {2017},
}