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The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells

Öhman, Josefine ; Sjölin, Elias ; Cundari, Maurizio LU ; Johansson, Fredrik LU ; Gilbert, Mike ; Boele, Henk-Jan LU ; Svensson, Pär and Rasmussen, Anders LU orcid (2024) In Cerebellum
Abstract

Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it... (More)

Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Cerebellum
publisher
Informa Healthcare
external identifiers
  • scopus:85187482329
  • pmid:38467957
ISSN
1473-4230
DOI
10.1007/s12311-024-01682-1
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
8cd20c53-04f6-473c-90a1-ff587c863543
date added to LUP
2024-03-18 11:15:54
date last changed
2024-04-16 01:49:29
@article{8cd20c53-04f6-473c-90a1-ff587c863543,
  abstract     = {{<p>Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.</p>}},
  author       = {{Öhman, Josefine and Sjölin, Elias and Cundari, Maurizio and Johansson, Fredrik and Gilbert, Mike and Boele, Henk-Jan and Svensson, Pär and Rasmussen, Anders}},
  issn         = {{1473-4230}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{Informa Healthcare}},
  series       = {{Cerebellum}},
  title        = {{The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells}},
  url          = {{http://dx.doi.org/10.1007/s12311-024-01682-1}},
  doi          = {{10.1007/s12311-024-01682-1}},
  year         = {{2024}},
}