The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men
(2000) In Clinical Endocrinology 52(4). p.8-493- Abstract
OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). The present study examined whether these associations are linked.
DESIGN AND PATIENTS: The association between serum levels of IGFBP-1, free testosterone and insulin on one hand and leptin on the other hand were investigated in 38 healthy men with a median age of 48 years (range 23-62 years).
RESULTS: Univariate analyses revealed that serum levels of leptin correlated negatively with serum free testosterone (r = - 0.42, P = 0.008) and with serum IGFBP-1 (r = - 0. 45, P = 0.005) and positively with body mass index (BMI; r = 0.46, P = 0.003) and... (More)
OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). The present study examined whether these associations are linked.
DESIGN AND PATIENTS: The association between serum levels of IGFBP-1, free testosterone and insulin on one hand and leptin on the other hand were investigated in 38 healthy men with a median age of 48 years (range 23-62 years).
RESULTS: Univariate analyses revealed that serum levels of leptin correlated negatively with serum free testosterone (r = - 0.42, P = 0.008) and with serum IGFBP-1 (r = - 0. 45, P = 0.005) and positively with body mass index (BMI; r = 0.46, P = 0.003) and serum insulin (r = 0.45, P = 0.004). Serum free testosterone correlated with IGFBP-1 (r = 0.42, P = 0.008) but not with serum insulin (r = - 0.08, ns). The correlations between leptin and free testosterone and between leptin and IGFBP-1 remained significant after adjustement for the influences of BMI and insulin. Forward stepwise multiple regression when BMI, insulin, testosterone and IGFBP-1 were entered in a model as independent variables and leptin as the dependent variable showed that BMI and IGFBP-1 were independent predictors of circulating leptin. These two parameters yielded an r 2 of 0.38, thereby together explaining approximately 40% of serum leptin.
CONCLUSION: Serum levels of free testosterone and IGFBP-1 correlate negatively with serum leptin in healthy nonobese men but this influence is dependent on the influence of IGFBP-1. The study therefore suggests an important impact of IGFBP-1 on the regulation of circulating leptin in young and middle-aged men.
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- author
- Erfurth, E M LU and Ahrén, B LU
- organization
- publishing date
- 2000-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Analysis of Variance, Biomarkers/blood, Humans, Insulin/blood, Insulin-Like Growth Factor Binding Protein 1/blood, Leptin/blood, Linear Models, Male, Middle Aged, Testosterone/blood
- in
- Clinical Endocrinology
- volume
- 52
- issue
- 4
- pages
- 8 - 493
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0034061509
- pmid:10762293
- ISSN
- 0300-0664
- DOI
- 10.1046/j.1365-2265.2000.00965.x
- language
- English
- LU publication?
- yes
- id
- 8d5f5b9a-2b96-4ceb-980f-e337e6e41c17
- date added to LUP
- 2023-11-20 09:05:47
- date last changed
- 2024-01-03 09:52:05
@article{8d5f5b9a-2b96-4ceb-980f-e337e6e41c17,
abstract = {{<p>OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). The present study examined whether these associations are linked.</p><p>DESIGN AND PATIENTS: The association between serum levels of IGFBP-1, free testosterone and insulin on one hand and leptin on the other hand were investigated in 38 healthy men with a median age of 48 years (range 23-62 years).</p><p>RESULTS: Univariate analyses revealed that serum levels of leptin correlated negatively with serum free testosterone (r = - 0.42, P = 0.008) and with serum IGFBP-1 (r = - 0. 45, P = 0.005) and positively with body mass index (BMI; r = 0.46, P = 0.003) and serum insulin (r = 0.45, P = 0.004). Serum free testosterone correlated with IGFBP-1 (r = 0.42, P = 0.008) but not with serum insulin (r = - 0.08, ns). The correlations between leptin and free testosterone and between leptin and IGFBP-1 remained significant after adjustement for the influences of BMI and insulin. Forward stepwise multiple regression when BMI, insulin, testosterone and IGFBP-1 were entered in a model as independent variables and leptin as the dependent variable showed that BMI and IGFBP-1 were independent predictors of circulating leptin. These two parameters yielded an r 2 of 0.38, thereby together explaining approximately 40% of serum leptin.</p><p>CONCLUSION: Serum levels of free testosterone and IGFBP-1 correlate negatively with serum leptin in healthy nonobese men but this influence is dependent on the influence of IGFBP-1. The study therefore suggests an important impact of IGFBP-1 on the regulation of circulating leptin in young and middle-aged men.</p>}},
author = {{Erfurth, E M and Ahrén, B}},
issn = {{0300-0664}},
keywords = {{Adult; Analysis of Variance; Biomarkers/blood; Humans; Insulin/blood; Insulin-Like Growth Factor Binding Protein 1/blood; Leptin/blood; Linear Models; Male; Middle Aged; Testosterone/blood}},
language = {{eng}},
number = {{4}},
pages = {{8--493}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Endocrinology}},
title = {{The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men}},
url = {{http://dx.doi.org/10.1046/j.1365-2265.2000.00965.x}},
doi = {{10.1046/j.1365-2265.2000.00965.x}},
volume = {{52}},
year = {{2000}},
}