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Coffee drinking and mortality in 10 European countries : A multinational cohort study

Gunter, Marc J ; Murphy, Neil ; Cross, Amanda J ; Dossus, Laure ; Dartois, Laureen ; Fagherazzi, Guy ; Kaaks, Rudolf ; Kühn, Tilman LU ; Boeing, Heiner and Aleksandrova, Krasimira , et al. (2017) In Annals of Internal Medicine 167(4). p.236-247
Abstract

Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean... (More)

Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; 7-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Coffee, mortality, Cohort study, European
in
Annals of Internal Medicine
volume
167
issue
4
pages
12 pages
publisher
American College of Physicians
external identifiers
  • scopus:85027464967
  • pmid:28693038
  • pmid:28693038
  • wos:000407797500012
ISSN
0003-4819
DOI
10.7326/M16-2945
language
English
LU publication?
yes
id
8ec306b8-2b87-44f7-afb0-7ae3112205b7
date added to LUP
2017-09-04 12:33:55
date last changed
2025-01-07 20:05:27
@article{8ec306b8-2b87-44f7-afb0-7ae3112205b7,
  abstract     = {{<p>Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend &lt; 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend &lt; 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend &lt; 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend &lt; 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; 7-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.</p>}},
  author       = {{Gunter, Marc J and Murphy, Neil and Cross, Amanda J and Dossus, Laure and Dartois, Laureen and Fagherazzi, Guy and Kaaks, Rudolf and Kühn, Tilman and Boeing, Heiner and Aleksandrova, Krasimira and Tjønneland, Anne and Olsen, Anja and Overvad, Kim and Larsen, Sofus Christian and Cornejo, Maria Luisa Redondo and Agudo, Antonio and Pérez, María José Sánchez and Altzibar, Jone M. and Navarro, Carmen and Ardanaz, Eva and Khaw, Kay Tee and Butterworth, Adam S. and Bradbury, Kathryn E and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Palli, Domenico and Grioni, Sara and Vineis, Paolo and Panico, Salvatore and Tumino, Rosario and Bueno de Mesquita, Bas and Siersema, Peter and Leenders, Max and Beulens, Joline W and Uiterwaal, Cuno U. and Wallström, Peter and Nilsson, Lena Maria and Landberg, Rikard and Weiderpass, Elisabete and Skeie, Guri and Braaten, Tonje and Brennan, Paul and Licaj, Idlir and Muller, David C and Sinha, Rashmi and Wareham, Nick and Riboli, Elio}},
  issn         = {{0003-4819}},
  keywords     = {{Coffee; mortality; Cohort study; European}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{4}},
  pages        = {{236--247}},
  publisher    = {{American College of Physicians}},
  series       = {{Annals of Internal Medicine}},
  title        = {{Coffee drinking and mortality in 10 European countries : A multinational cohort study}},
  url          = {{http://dx.doi.org/10.7326/M16-2945}},
  doi          = {{10.7326/M16-2945}},
  volume       = {{167}},
  year         = {{2017}},
}