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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

Rydell, Andreas ; Nerpin, Elisabet ; Zhou, Xingwu ; Lind, Lars ; Lindberg, Eva ; Haglöw, Jenny Theorell ; Fall, Tove ; Janson, Christer ; Lisspers, Karin and Elmståhl, Sölve LU , et al. (2023) In ERJ open research 9(2).
Abstract

Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio. Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease-and metabolism-linked proteins in relation to FEV1, FVC (both % predicted)... (More)

Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio. Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease-and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort. Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1 /FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity. Conclusions Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ open research
volume
9
issue
2
article number
00321-2022
publisher
European Respiratory Society
external identifiers
  • pmid:37009020
  • scopus:85152694714
ISSN
2312-0541
DOI
10.1183/23120541.00321-2022
language
English
LU publication?
yes
id
8f09c38e-b0c1-4c63-bf1f-4e43b679d79a
date added to LUP
2023-07-13 12:19:53
date last changed
2024-04-19 23:22:50
@article{8f09c38e-b0c1-4c63-bf1f-4e43b679d79a,
  abstract     = {{<p>Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV<sub>1</sub>), forced vital capacity (FVC) and FEV<sub>1</sub>/FVC ratio. Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease-and metabolism-linked proteins in relation to FEV<sub>1</sub>, FVC (both % predicted) and FEV<sub>1</sub>/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort. Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV<sub>1</sub> and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV<sub>1</sub> /FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity. Conclusions Five proteins were associated with both FEV<sub>1</sub> and FVC. Four proteins associated with only FVC and none with FEV<sub>1</sub>/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.</p>}},
  author       = {{Rydell, Andreas and Nerpin, Elisabet and Zhou, Xingwu and Lind, Lars and Lindberg, Eva and Haglöw, Jenny Theorell and Fall, Tove and Janson, Christer and Lisspers, Karin and Elmståhl, Sölve and Zaigham, Suneela and Melander, Olle and Nilsson, Peter M. and Ärnlöv, Johan and Malinovschi, Andrei}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ open research}},
  title        = {{Cardiovascular disease-linked plasma proteins are mainly associated with lung volume}},
  url          = {{http://dx.doi.org/10.1183/23120541.00321-2022}},
  doi          = {{10.1183/23120541.00321-2022}},
  volume       = {{9}},
  year         = {{2023}},
}