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Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö diet and cancer cohort

Hellstrand, Sophie LU ; Ericson, Ulrika LU ; Schulz, Christina Alexandra LU ; Drake, Isabel LU ; Gullberg, Bo LU ; Hedblad, Bo LU ; Engström, Gunnar LU ; Orho-Melander, Marju LU and Sonestedt, Emily LU (2016) In Genes & Nutrition 11(1).
Abstract

Background: By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods: We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants’ dietary... (More)

Background: By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods: We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants’ dietary intake, assessed by a modified diet history method, was ranked according to a diet quality index that included six dietary components: saturated fat, polyunsaturated fat, fish, fiber, fruit and vegetables, and sucrose. Results: The GRSLDL-C (P=5×10-6) and GRSHDL-C (P = 0.02) but not GRSTG (P = 0.08) were significantly associated with CVD risk. No significant interaction between the GRSs and diet quality was observed on CVD risk (P > 0.39). A high compared to a low diet quality attenuated the association between GRSLDL-C and the risk of incident ischemic stroke (P interaction = 0.01). Conclusion: We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cholesterol, Epidemiology, Lipoproteins, Nutrition, Triglycerides
in
Genes & Nutrition
volume
11
issue
1
publisher
New Century Health Publishers
external identifiers
  • scopus:84979276978
  • wos:000380146400001
ISSN
1555-8932
DOI
10.1186/s12263-016-0536-0
language
English
LU publication?
yes
id
914f8a6e-ac29-4763-abcc-64369e9d6764
date added to LUP
2016-09-08 17:05:52
date last changed
2017-01-09 11:44:17
@article{914f8a6e-ac29-4763-abcc-64369e9d6764,
  abstract     = {<p>Background: By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods: We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants’ dietary intake, assessed by a modified diet history method, was ranked according to a diet quality index that included six dietary components: saturated fat, polyunsaturated fat, fish, fiber, fruit and vegetables, and sucrose. Results: The GRS<sub>LDL-C</sub> (P=5×10<sup>-6</sup>) and GRS<sub>HDL-C</sub> (P = 0.02) but not GRS<sub>TG</sub> (P = 0.08) were significantly associated with CVD risk. No significant interaction between the GRSs and diet quality was observed on CVD risk (P &gt; 0.39). A high compared to a low diet quality attenuated the association between GRSLDL-C and the risk of incident ischemic stroke (P interaction = 0.01). Conclusion: We found some evidence of an interaction between diet quality and GRS<sub>LDL-C</sub> on ischemic stroke.</p>},
  articleno    = {20},
  author       = {Hellstrand, Sophie and Ericson, Ulrika and Schulz, Christina Alexandra and Drake, Isabel and Gullberg, Bo and Hedblad, Bo and Engström, Gunnar and Orho-Melander, Marju and Sonestedt, Emily},
  issn         = {1555-8932},
  keyword      = {Cholesterol,Epidemiology,Lipoproteins,Nutrition,Triglycerides},
  language     = {eng},
  number       = {1},
  publisher    = {New Century Health Publishers},
  series       = {Genes & Nutrition},
  title        = {Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö diet and cancer cohort},
  url          = {http://dx.doi.org/10.1186/s12263-016-0536-0},
  volume       = {11},
  year         = {2016},
}