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Perinatal risk factors for developmental coordination disorder in children born extremely preterm

Bolk, Jenny ; Källén, Karin LU ; Farooqi, Aijaz ; Hafström, Maria ; Fellman, Vineta LU orcid ; Åden, Ulrika LU and Serenius, Fredrik LU (2023) In Acta Paediatrica, International Journal of Paediatrics 112(4). p.675-685
Abstract

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Second Edition. Perinatal risk factors were evaluated using multivariable logistic regression. Results: DCD was present in 84/226 (37.2%) children. Of the risk factors known at 40 weeks gestation, independent and significant risk factors for DCD were: mother's age at delivery (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.07–2.80);... (More)

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Second Edition. Perinatal risk factors were evaluated using multivariable logistic regression. Results: DCD was present in 84/226 (37.2%) children. Of the risk factors known at 40 weeks gestation, independent and significant risk factors for DCD were: mother's age at delivery (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.07–2.80); pre-eclampsia (2.79, 1.14–6.80); mother born in a non-Nordic country (2.23, 1.00–4.99); gestational age per week increase (0.70, 0.50–0.99) and retinopathy of prematurity (2.48, 1.26–4.87). Of factors known at discharge, postnatal steroids exposure (2.24, 1.13–4.46) and mechanical ventilation (1.76, 1.06–2.09) were independent risk factors when added to the model in separate analyses. Conclusion: The risk of DCD in children born extremely preterm was multifactorial and associated with gestational age largely mediated by ROP, maternal factors, pre-eclampsia, administration of postnatal steroids and mechanical ventilation. These risk factors are common among children born extremely preterm, contributing to their high risk of DCD.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
developmental coordination disorder, perinatal, preterm, risk factors
in
Acta Paediatrica, International Journal of Paediatrics
volume
112
issue
4
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85149807270
  • pmid:36587369
ISSN
0803-5253
DOI
10.1111/apa.16651
language
English
LU publication?
yes
id
92f77fd0-d17d-4bca-8857-d84d9fcb7e14
date added to LUP
2023-04-24 13:52:06
date last changed
2024-04-19 21:00:12
@article{92f77fd0-d17d-4bca-8857-d84d9fcb7e14,
  abstract     = {{<p>Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Second Edition. Perinatal risk factors were evaluated using multivariable logistic regression. Results: DCD was present in 84/226 (37.2%) children. Of the risk factors known at 40 weeks gestation, independent and significant risk factors for DCD were: mother's age at delivery (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.07–2.80); pre-eclampsia (2.79, 1.14–6.80); mother born in a non-Nordic country (2.23, 1.00–4.99); gestational age per week increase (0.70, 0.50–0.99) and retinopathy of prematurity (2.48, 1.26–4.87). Of factors known at discharge, postnatal steroids exposure (2.24, 1.13–4.46) and mechanical ventilation (1.76, 1.06–2.09) were independent risk factors when added to the model in separate analyses. Conclusion: The risk of DCD in children born extremely preterm was multifactorial and associated with gestational age largely mediated by ROP, maternal factors, pre-eclampsia, administration of postnatal steroids and mechanical ventilation. These risk factors are common among children born extremely preterm, contributing to their high risk of DCD.</p>}},
  author       = {{Bolk, Jenny and Källén, Karin and Farooqi, Aijaz and Hafström, Maria and Fellman, Vineta and Åden, Ulrika and Serenius, Fredrik}},
  issn         = {{0803-5253}},
  keywords     = {{developmental coordination disorder; perinatal; preterm; risk factors}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{675--685}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Perinatal risk factors for developmental coordination disorder in children born extremely preterm}},
  url          = {{http://dx.doi.org/10.1111/apa.16651}},
  doi          = {{10.1111/apa.16651}},
  volume       = {{112}},
  year         = {{2023}},
}