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Gastric inhibitory polypeptide stimulates synthesis of pancreatic lipase and colipase in rat.

Duan, Rui-Dong LU and Erlanson-Albertsson, Charlotte LU (1992) In American Journal of Physiology: Gastrointestinal and Liver Physiology 262(5 Pt 1). p.779-784
Abstract
Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more... (More)
Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more prominent. Injection of GIP for 5 days at a dose of 30 micrograms.kg-1.day-1 increased colipase and lipase contents by 52 and 25%, and their corresponding mRNAs by 60 and 160%, respectively. The amylase mRNA was not changed by injection of GIP. It is concluded that GIP has a specific stimulatory effect on the synthesis of pancreatic lipase and colipase at both pretranslational and translational levels. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Physiology: Gastrointestinal and Liver Physiology
volume
262
issue
5 Pt 1
pages
779 - 784
publisher
American Physiological Society
external identifiers
  • scopus:0026725629
ISSN
1522-1547
DOI
10.1152/ajpgi.1992.262.5.G779
language
English
LU publication?
yes
id
9401ccb1-bf5d-44bf-8b0a-af936b2cd44b
date added to LUP
2019-02-03 09:35:22
date last changed
2024-01-15 13:44:27
@article{9401ccb1-bf5d-44bf-8b0a-af936b2cd44b,
  abstract     = {{Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more prominent. Injection of GIP for 5 days at a dose of 30 micrograms.kg-1.day-1 increased colipase and lipase contents by 52 and 25%, and their corresponding mRNAs by 60 and 160%, respectively. The amylase mRNA was not changed by injection of GIP. It is concluded that GIP has a specific stimulatory effect on the synthesis of pancreatic lipase and colipase at both pretranslational and translational levels.}},
  author       = {{Duan, Rui-Dong and Erlanson-Albertsson, Charlotte}},
  issn         = {{1522-1547}},
  language     = {{eng}},
  number       = {{5 Pt 1}},
  pages        = {{779--784}},
  publisher    = {{American Physiological Society}},
  series       = {{American Journal of Physiology: Gastrointestinal and Liver Physiology}},
  title        = {{Gastric inhibitory polypeptide stimulates synthesis of pancreatic lipase and colipase in rat.}},
  url          = {{http://dx.doi.org/10.1152/ajpgi.1992.262.5.G779}},
  doi          = {{10.1152/ajpgi.1992.262.5.G779}},
  volume       = {{262}},
  year         = {{1992}},
}