Gastric inhibitory polypeptide stimulates synthesis of pancreatic lipase and colipase in rat.
(1992) In American Journal of Physiology: Gastrointestinal and Liver Physiology 262(5 Pt 1). p.779-784- Abstract
- Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more... (More)
- Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more prominent. Injection of GIP for 5 days at a dose of 30 micrograms.kg-1.day-1 increased colipase and lipase contents by 52 and 25%, and their corresponding mRNAs by 60 and 160%, respectively. The amylase mRNA was not changed by injection of GIP. It is concluded that GIP has a specific stimulatory effect on the synthesis of pancreatic lipase and colipase at both pretranslational and translational levels. (Less)
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- author
- Duan, Rui-Dong LU and Erlanson-Albertsson, Charlotte LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Physiology: Gastrointestinal and Liver Physiology
- volume
- 262
- issue
- 5 Pt 1
- pages
- 779 - 784
- publisher
- American Physiological Society
- external identifiers
-
- scopus:0026725629
- ISSN
- 1522-1547
- DOI
- 10.1152/ajpgi.1992.262.5.G779
- language
- English
- LU publication?
- yes
- id
- 9401ccb1-bf5d-44bf-8b0a-af936b2cd44b
- date added to LUP
- 2019-02-03 09:35:22
- date last changed
- 2024-01-15 13:44:27
@article{9401ccb1-bf5d-44bf-8b0a-af936b2cd44b, abstract = {{Effects of short-term infusion and long-term injection of gastric inhibitory polypeptide (GIP) on changes in pancreatic lipase and colipase contents in rats were studied, and mRNAs encoding for lipase and colipase were determined by Northern blot hybridization with specific cDNA probes. GIP infused at a dose of 3 micrograms/h for 24 h significantly increased the pancreatic lipase content by 34% (P less than 0.05) but had no significant effect on colipase and amylase contents. No change in mRNAs encoding for these proteins was found after infusion of GIP for 24 h. Injection of GIP (5-60 micrograms/kg) three times a day for 5 days dose dependently increased the contents of lipase and colipase, with the increase in colipase being more prominent. Injection of GIP for 5 days at a dose of 30 micrograms.kg-1.day-1 increased colipase and lipase contents by 52 and 25%, and their corresponding mRNAs by 60 and 160%, respectively. The amylase mRNA was not changed by injection of GIP. It is concluded that GIP has a specific stimulatory effect on the synthesis of pancreatic lipase and colipase at both pretranslational and translational levels.}}, author = {{Duan, Rui-Dong and Erlanson-Albertsson, Charlotte}}, issn = {{1522-1547}}, language = {{eng}}, number = {{5 Pt 1}}, pages = {{779--784}}, publisher = {{American Physiological Society}}, series = {{American Journal of Physiology: Gastrointestinal and Liver Physiology}}, title = {{Gastric inhibitory polypeptide stimulates synthesis of pancreatic lipase and colipase in rat.}}, url = {{http://dx.doi.org/10.1152/ajpgi.1992.262.5.G779}}, doi = {{10.1152/ajpgi.1992.262.5.G779}}, volume = {{262}}, year = {{1992}}, }