Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis
Whybra, Catharina ; Källén, Karin LU ; Hansson, Stefan R. LU
and Gunnarsson, Rolf
(2020)
In Acta Paediatrica, International Journal of Paediatrics
109(12).
p.2570-2577
- Abstract
Aim: The study was designed to document the incidence of non-immune hydrops fetalis (NIHF) at birth and characterise associated outcomes and obstetric complications. Methods: Data on more than 1.9 million births were extracted from the Swedish Birth Register for 1997-2015. Pregnancies not affected by NIHF served as controls. National registers on mortality and hospitalisations provided follow-up information. Results: There were 309 cases of NIHF at birth corresponding to an incidence of 1.6 per 10 000, lower than in previous studies. NIHF was more frequent in mothers aged ≥35 years and with a history of stillbirth. Preterm delivery occurred in 77.7% in the NIHF group, including 31.7% before 32 weeks of gestation. Multiple births and... (More)
Aim: The study was designed to document the incidence of non-immune hydrops fetalis (NIHF) at birth and characterise associated outcomes and obstetric complications. Methods: Data on more than 1.9 million births were extracted from the Swedish Birth Register for 1997-2015. Pregnancies not affected by NIHF served as controls. National registers on mortality and hospitalisations provided follow-up information. Results: There were 309 cases of NIHF at birth corresponding to an incidence of 1.6 per 10 000, lower than in previous studies. NIHF was more frequent in mothers aged ≥35 years and with a history of stillbirth. Preterm delivery occurred in 77.7% in the NIHF group, including 31.7% before 32 weeks of gestation. Multiple births and Caesarean sections were reported more frequent in the NIHF group. NIHF was associated with poor outcome with 14.6% stillbirths and in 26.5% early neonatal death. Overall, 58.7% of live-born children with NIHF were alive at 12 months compared with 99.7% of controls. The most common causes of death were cardiovascular diseases and thoracic abnormalities. Conclusion: NIHF at birth is associated with obstetric complications and poor prognosis for the neonate related to underlying disease. The low incidence of NIHF observed in this study may reflect well-developed antenatal care.
(Less)
- author
- Whybra, Catharina
; Källén, Karin
LU
; Hansson, Stefan R.
LU
and Gunnarsson, Rolf
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- incidence, non-immune hydrops fetalis, obstetric complications, poor prognosis, population study
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 109
- issue
- 12
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32187745
- scopus:85084138491
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.15260
- language
- English
- LU publication?
- yes
- id
- 9583a293-35cc-495c-86fe-a52a61fd8478
- date added to LUP
- 2021-01-15 12:07:21
- date last changed
- 2024-04-18 00:21:56
@article{9583a293-35cc-495c-86fe-a52a61fd8478,
abstract = {{<p>Aim: The study was designed to document the incidence of non-immune hydrops fetalis (NIHF) at birth and characterise associated outcomes and obstetric complications. Methods: Data on more than 1.9 million births were extracted from the Swedish Birth Register for 1997-2015. Pregnancies not affected by NIHF served as controls. National registers on mortality and hospitalisations provided follow-up information. Results: There were 309 cases of NIHF at birth corresponding to an incidence of 1.6 per 10 000, lower than in previous studies. NIHF was more frequent in mothers aged ≥35 years and with a history of stillbirth. Preterm delivery occurred in 77.7% in the NIHF group, including 31.7% before 32 weeks of gestation. Multiple births and Caesarean sections were reported more frequent in the NIHF group. NIHF was associated with poor outcome with 14.6% stillbirths and in 26.5% early neonatal death. Overall, 58.7% of live-born children with NIHF were alive at 12 months compared with 99.7% of controls. The most common causes of death were cardiovascular diseases and thoracic abnormalities. Conclusion: NIHF at birth is associated with obstetric complications and poor prognosis for the neonate related to underlying disease. The low incidence of NIHF observed in this study may reflect well-developed antenatal care.</p>}},
author = {{Whybra, Catharina and Källén, Karin and Hansson, Stefan R. and Gunnarsson, Rolf}},
issn = {{0803-5253}},
keywords = {{incidence; non-immune hydrops fetalis; obstetric complications; poor prognosis; population study}},
language = {{eng}},
number = {{12}},
pages = {{2570--2577}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis}},
url = {{http://dx.doi.org/10.1111/apa.15260}},
doi = {{10.1111/apa.15260}},
volume = {{109}},
year = {{2020}},
}