Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients
(2020) In ERJ Open Research 6. p.1-10- Abstract
Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.
Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC... (More)
Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.
Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC and not intubated (NB). The PEx samples were analysed for the most common phospholipids in surfactant using liquid-chromatography-mass-spectrometry (LCMS).
Results: MV-NSCLC and MV-C had significantly lower numbers of particles exhaled per minute (particle flow rate; PFR) compared to NB. MV-NSCLC and MV-C also had a siginificantly lower amount of phospholipids in PEx when compared to NB. MV-NSCLC had a significantly lower amount of surfactant A compared to NB.
Conclusion: We have established the feasibility of the PExA device. Particles could be collected and analysed. We observed lower PFR from MV compared to NB. High PFR during MV may be due to more frequent opening and closing of the airways, known to be harmful to the lung. Online use of the PExA device might be used to monitor and personalise settings for mechanical ventilation to lower the risk of lung damage.
(Less)
- author
- Broberg, Ellen LU ; Andreasson, Jesper LU ; Fakhro, Mohammed LU ; Olin, Anna-Carin ; Wagner, Darcy LU ; Hyllén, Snejana LU and Lindstedt, Sandra LU
- organization
-
- Pediatric anesthesia and intensive care (research group)
- Anesthesiology and Intensive Care
- DCD transplantation of lungs (research group)
- Thoracic Surgery
- Clinical and experimental lung transplantation (research group)
- WCMM-Wallenberg Centre for Molecular Medicine
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- Lung Bioengineering and Regeneration (research group)
- Stem Cell Center
- Minimal invasive cardiac surgery in valvular heart disease (research group)
- publishing date
- 2020-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ERJ Open Research
- volume
- 6
- article number
- 00198-2019
- pages
- 1 - 10
- publisher
- European Respiratory Society
- external identifiers
-
- pmid:32055633
- scopus:85092078423
- ISSN
- 2312-0541
- DOI
- 10.1183/23120541.00198-2019
- language
- English
- LU publication?
- yes
- additional info
- Copyright ©ERS 2020.
- id
- 95cbb32a-00ed-4efe-9d9e-9cfcb81e7a8e
- date added to LUP
- 2020-02-19 14:27:58
- date last changed
- 2024-08-23 01:48:01
@article{95cbb32a-00ed-4efe-9d9e-9cfcb81e7a8e, abstract = {{<p>Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.</p><p>Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC and not intubated (NB). The PEx samples were analysed for the most common phospholipids in surfactant using liquid-chromatography-mass-spectrometry (LCMS).</p><p>Results: MV-NSCLC and MV-C had significantly lower numbers of particles exhaled per minute (particle flow rate; PFR) compared to NB. MV-NSCLC and MV-C also had a siginificantly lower amount of phospholipids in PEx when compared to NB. MV-NSCLC had a significantly lower amount of surfactant A compared to NB.</p><p>Conclusion: We have established the feasibility of the PExA device. Particles could be collected and analysed. We observed lower PFR from MV compared to NB. High PFR during MV may be due to more frequent opening and closing of the airways, known to be harmful to the lung. Online use of the PExA device might be used to monitor and personalise settings for mechanical ventilation to lower the risk of lung damage.</p>}}, author = {{Broberg, Ellen and Andreasson, Jesper and Fakhro, Mohammed and Olin, Anna-Carin and Wagner, Darcy and Hyllén, Snejana and Lindstedt, Sandra}}, issn = {{2312-0541}}, language = {{eng}}, pages = {{1--10}}, publisher = {{European Respiratory Society}}, series = {{ERJ Open Research}}, title = {{Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients}}, url = {{http://dx.doi.org/10.1183/23120541.00198-2019}}, doi = {{10.1183/23120541.00198-2019}}, volume = {{6}}, year = {{2020}}, }