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Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients

Broberg, Ellen LU ; Andreasson, Jesper LU ; Fakhro, Mohammed LU ; Olin, Anna-Carin ; Wagner, Darcy LU orcid ; Hyllén, Snejana LU and Lindstedt, Sandra LU (2020) In ERJ Open Research 6. p.1-10
Abstract

Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.

Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC... (More)

Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.

Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC and not intubated (NB). The PEx samples were analysed for the most common phospholipids in surfactant using liquid-chromatography-mass-spectrometry (LCMS).

Results: MV-NSCLC and MV-C had significantly lower numbers of particles exhaled per minute (particle flow rate; PFR) compared to NB. MV-NSCLC and MV-C also had a siginificantly lower amount of phospholipids in PEx when compared to NB. MV-NSCLC had a significantly lower amount of surfactant A compared to NB.

Conclusion: We have established the feasibility of the PExA device. Particles could be collected and analysed. We observed lower PFR from MV compared to NB. High PFR during MV may be due to more frequent opening and closing of the airways, known to be harmful to the lung. Online use of the PExA device might be used to monitor and personalise settings for mechanical ventilation to lower the risk of lung damage.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ Open Research
volume
6
article number
00198-2019
pages
1 - 10
publisher
European Respiratory Society
external identifiers
  • pmid:32055633
  • scopus:85092078423
ISSN
2312-0541
DOI
10.1183/23120541.00198-2019
language
English
LU publication?
yes
additional info
Copyright ©ERS 2020.
id
95cbb32a-00ed-4efe-9d9e-9cfcb81e7a8e
date added to LUP
2020-02-19 14:27:58
date last changed
2024-06-13 18:55:28
@article{95cbb32a-00ed-4efe-9d9e-9cfcb81e7a8e,
  abstract     = {{<p>Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC.</p><p>Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC and not intubated (NB). The PEx samples were analysed for the most common phospholipids in surfactant using liquid-chromatography-mass-spectrometry (LCMS).</p><p>Results: MV-NSCLC and MV-C had significantly lower numbers of particles exhaled per minute (particle flow rate; PFR) compared to NB. MV-NSCLC and MV-C also had a siginificantly lower amount of phospholipids in PEx when compared to NB. MV-NSCLC had a significantly lower amount of surfactant A compared to NB.</p><p>Conclusion: We have established the feasibility of the PExA device. Particles could be collected and analysed. We observed lower PFR from MV compared to NB. High PFR during MV may be due to more frequent opening and closing of the airways, known to be harmful to the lung. Online use of the PExA device might be used to monitor and personalise settings for mechanical ventilation to lower the risk of lung damage.</p>}},
  author       = {{Broberg, Ellen and Andreasson, Jesper and Fakhro, Mohammed and Olin, Anna-Carin and Wagner, Darcy and Hyllén, Snejana and Lindstedt, Sandra}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  pages        = {{1--10}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ Open Research}},
  title        = {{Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients}},
  url          = {{http://dx.doi.org/10.1183/23120541.00198-2019}},
  doi          = {{10.1183/23120541.00198-2019}},
  volume       = {{6}},
  year         = {{2020}},
}