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Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression A Volumetric Magnetic Resonance Imaging Study

Nordanskog, Pia; Dahlstrand, Ulf LU ; Lindén, Magnus LU ; Larsson, Elna-Marie; Knutsson, Linda LU and Johanson, Aki LU (2010) In Journal of ECT 26(1). p.62-67
Abstract
Background: Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression. Methods: Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T... (More)
Background: Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression. Methods: Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T magnetic resonance imaging within 1 week before and after the ECT series. Each hippocampus was manually outlined on coronal slices, and the volume was calculated. Results: The left as well as the right hippocampal volume increased significantly after ECT. Conclusions: The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurogenesis, MRI, hippocampus, ECT, depression
in
Journal of ECT
volume
26
issue
1
pages
62 - 67
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000275571000017
  • scopus:77649315720
ISSN
1533-4112
DOI
10.1097/YCT.0b013e3181a95da8
language
English
LU publication?
yes
id
95f495de-623b-4cd5-a152-abf1351570a2 (old id 1587990)
date added to LUP
2010-04-22 11:28:12
date last changed
2018-08-05 03:05:43
@article{95f495de-623b-4cd5-a152-abf1351570a2,
  abstract     = {Background: Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression. Methods: Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T magnetic resonance imaging within 1 week before and after the ECT series. Each hippocampus was manually outlined on coronal slices, and the volume was calculated. Results: The left as well as the right hippocampal volume increased significantly after ECT. Conclusions: The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression.},
  author       = {Nordanskog, Pia and Dahlstrand, Ulf and Lindén, Magnus and Larsson, Elna-Marie and Knutsson, Linda and Johanson, Aki},
  issn         = {1533-4112},
  keyword      = {neurogenesis,MRI,hippocampus,ECT,depression},
  language     = {eng},
  number       = {1},
  pages        = {62--67},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of ECT},
  title        = {Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression A Volumetric Magnetic Resonance Imaging Study},
  url          = {http://dx.doi.org/10.1097/YCT.0b013e3181a95da8},
  volume       = {26},
  year         = {2010},
}