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Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study

Tonning Olsson, Ingrid LU orcid ; Lundgren, Johan LU ; Hjorth, Lars LU ; Munck Af Rosenschöld, Per LU orcid ; Hammar, Åsa LU and Perrin, Sean LU orcid (2024) In Child Neuropsychology 30(1). p.22-44
Abstract

Survivors of Pediatric Brain Tumors (PBTs) treated with cranial radiation therapy (CRT) often experience a decline in neurocognitive test scores. Less is known about the neurocognitive development of non-irradiated survivors of PBTs. The aim of this study was to statistically model neurocognitive development after PBT in both irradiated and non-irradiated survivors and to find clinical variables associated with the rate of decline in neurocognitive scores. A total of 151 survivors were included in the study. Inclusion criteria: Diagnosis of PBT between 2001 and 2013 or earlier diagnosis of PBT and turning 18 years of age between 2006 and 2013. Exclusion criteria: Death within a year from diagnosis, neurocutaneous syndromes, severe... (More)

Survivors of Pediatric Brain Tumors (PBTs) treated with cranial radiation therapy (CRT) often experience a decline in neurocognitive test scores. Less is known about the neurocognitive development of non-irradiated survivors of PBTs. The aim of this study was to statistically model neurocognitive development after PBT in both irradiated and non-irradiated survivors and to find clinical variables associated with the rate of decline in neurocognitive scores. A total of 151 survivors were included in the study. Inclusion criteria: Diagnosis of PBT between 2001 and 2013 or earlier diagnosis of PBT and turning 18 years of age between 2006 and 2013. Exclusion criteria: Death within a year from diagnosis, neurocutaneous syndromes, severe intellectual disability. Clinical neurocognitive data were collected retrospectively from medical records. Multilevel linear modeling was used to evaluate the rate of decline in neurocognitive measures and factors associated with the same. A decline was found in most measures for both irradiated and non-irradiated survivors. Ventriculo-peritoneal (VP) shunting and treatment with whole-brain radiation therapy (WBRT) were associated with a faster decline in neurocognitive scores. Male sex and supratentorial lateral tumor were associated with lower scores. Verbal learning measures were either stable or improving. Survivors of PBTs show a pattern of decline in neurocognitive scores irrespective of treatment received, which suggests the need for routine screening for neurocognitive rehabilitation. However, survivors treated with WBRT and/or a VP shunt declined at a faster rate and appear to be at the highest risk of negative neurocognitive outcomes and to have the greatest need for neurocognitive rehabilitation.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
late complications, longitudinal, neurocognition, Pediatric brain tumor, survivorship
in
Child Neuropsychology
volume
30
issue
1
pages
22 - 44
publisher
Psychology Press
external identifiers
  • pmid:36744788
  • scopus:85147657151
ISSN
0929-7049
DOI
10.1080/09297049.2023.2172149
language
English
LU publication?
yes
id
9720899b-52de-4db8-919f-7c46e4500a0b
date added to LUP
2023-02-21 09:46:40
date last changed
2024-07-11 19:41:54
@article{9720899b-52de-4db8-919f-7c46e4500a0b,
  abstract     = {{<p>Survivors of Pediatric Brain Tumors (PBTs) treated with cranial radiation therapy (CRT) often experience a decline in neurocognitive test scores. Less is known about the neurocognitive development of non-irradiated survivors of PBTs. The aim of this study was to statistically model neurocognitive development after PBT in both irradiated and non-irradiated survivors and to find clinical variables associated with the rate of decline in neurocognitive scores. A total of 151 survivors were included in the study. Inclusion criteria: Diagnosis of PBT between 2001 and 2013 or earlier diagnosis of PBT and turning 18 years of age between 2006 and 2013. Exclusion criteria: Death within a year from diagnosis, neurocutaneous syndromes, severe intellectual disability. Clinical neurocognitive data were collected retrospectively from medical records. Multilevel linear modeling was used to evaluate the rate of decline in neurocognitive measures and factors associated with the same. A decline was found in most measures for both irradiated and non-irradiated survivors. Ventriculo-peritoneal (VP) shunting and treatment with whole-brain radiation therapy (WBRT) were associated with a faster decline in neurocognitive scores. Male sex and supratentorial lateral tumor were associated with lower scores. Verbal learning measures were either stable or improving. Survivors of PBTs show a pattern of decline in neurocognitive scores irrespective of treatment received, which suggests the need for routine screening for neurocognitive rehabilitation. However, survivors treated with WBRT and/or a VP shunt declined at a faster rate and appear to be at the highest risk of negative neurocognitive outcomes and to have the greatest need for neurocognitive rehabilitation.</p>}},
  author       = {{Tonning Olsson, Ingrid and Lundgren, Johan and Hjorth, Lars and Munck Af Rosenschöld, Per and Hammar, Åsa and Perrin, Sean}},
  issn         = {{0929-7049}},
  keywords     = {{late complications; longitudinal; neurocognition; Pediatric brain tumor; survivorship}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{22--44}},
  publisher    = {{Psychology Press}},
  series       = {{Child Neuropsychology}},
  title        = {{Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1080/09297049.2023.2172149}},
  doi          = {{10.1080/09297049.2023.2172149}},
  volume       = {{30}},
  year         = {{2024}},
}