Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The mosaic oat genome gives insights into a uniquely healthy cereal crop

Kamal, Nadia ; Tsardakas Renhuldt, Nikos LU orcid ; Bentzer, Johan LU ; Gundlach, Heidrun ; Haberer, Georg ; Juhász, Angéla ; Lux, Thomas ; Bose, Utpal ; Tye-Din, Jason A and Lang, Daniel , et al. (2022) In Nature 606(7912). p.113-119
Abstract

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid (Avena insularis, CCDD, 2n = 4x = 28) progenitors. We reveal the mosaic structure of the oat genome, trace large-scale... (More)

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid (Avena insularis, CCDD, 2n = 4x = 28) progenitors. We reveal the mosaic structure of the oat genome, trace large-scale genomic reorganizations in the polyploidization history of oat and illustrate a breeding barrier associated with the genome architecture of oat. We showcase detailed analyses of gene families implicated in human health and nutrition, which adds to the evidence supporting oat safety in gluten-free diets, and we perform mapping-by-sequencing of an agronomic trait related to water-use efficiency. This resource for the Avena genus will help to leverage knowledge from other cereal genomes, improve understanding of basic oat biology and accelerate genomics-assisted breeding and reanalysis of quantitative trait studies.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Avena/genetics, Diploidy, Edible Grain/genetics, Genome, Plant/genetics, Mosaicism, Plant Breeding, Tetraploidy
in
Nature
volume
606
issue
7912
pages
113 - 119
publisher
Nature Publishing Group
external identifiers
  • pmid:35585233
  • scopus:85130230490
ISSN
0028-0836
DOI
10.1038/s41586-022-04732-y
language
English
LU publication?
yes
additional info
© 2022. The Author(s).
id
97c46148-61a3-46ab-aa38-ee53f101f3dd
date added to LUP
2022-12-08 10:50:15
date last changed
2024-12-28 07:33:54
@article{97c46148-61a3-46ab-aa38-ee53f101f3dd,
  abstract     = {{<p>Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid (Avena insularis, CCDD, 2n = 4x = 28) progenitors. We reveal the mosaic structure of the oat genome, trace large-scale genomic reorganizations in the polyploidization history of oat and illustrate a breeding barrier associated with the genome architecture of oat. We showcase detailed analyses of gene families implicated in human health and nutrition, which adds to the evidence supporting oat safety in gluten-free diets, and we perform mapping-by-sequencing of an agronomic trait related to water-use efficiency. This resource for the Avena genus will help to leverage knowledge from other cereal genomes, improve understanding of basic oat biology and accelerate genomics-assisted breeding and reanalysis of quantitative trait studies.</p>}},
  author       = {{Kamal, Nadia and Tsardakas Renhuldt, Nikos and Bentzer, Johan and Gundlach, Heidrun and Haberer, Georg and Juhász, Angéla and Lux, Thomas and Bose, Utpal and Tye-Din, Jason A and Lang, Daniel and van Gessel, Nico and Reski, Ralf and Fu, Yong-Bi and Spégel, Peter and Ceplitis, Alf and Himmelbach, Axel and Waters, Amanda J and Bekele, Wubishet A and Colgrave, Michelle L and Hansson, Mats and Stein, Nils and Mayer, Klaus F X and Jellen, Eric N and Maughan, Peter J and Tinker, Nicholas A and Mascher, Martin and Olsson, Olof and Spannagl, Manuel and Sirijovski, Nick}},
  issn         = {{0028-0836}},
  keywords     = {{Avena/genetics; Diploidy; Edible Grain/genetics; Genome, Plant/genetics; Mosaicism; Plant Breeding; Tetraploidy}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{7912}},
  pages        = {{113--119}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature}},
  title        = {{The mosaic oat genome gives insights into a uniquely healthy cereal crop}},
  url          = {{http://dx.doi.org/10.1038/s41586-022-04732-y}},
  doi          = {{10.1038/s41586-022-04732-y}},
  volume       = {{606}},
  year         = {{2022}},
}