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Clinical landscape of cancer metastases

Riihimäki, Matias LU ; Thomsen, Hauke LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2018) In Cancer Medicine 7(11). p.5534-5542
Abstract

Population-based data on metastatic patterns are lacking because cancer registries seldom record metastases. This study uses a novel population-based approach to identify metastases and describes metastatic pathways from 14 common primary cancers to 12 specific metastatic sites. A total of 179 581 patients with metastatic cancer were identified from the Swedish Cancer Registry and metastatic sites were identified using the Cause of Death Register and the National Patient Register. Patterns of metastatic spread were described across age and sex. In men, colorectal cancer was the main source of lung, peritoneal, and liver metastases. Lung cancer was the main origin of pleural and nervous system metastases. Prostate cancer dominated bone... (More)

Population-based data on metastatic patterns are lacking because cancer registries seldom record metastases. This study uses a novel population-based approach to identify metastases and describes metastatic pathways from 14 common primary cancers to 12 specific metastatic sites. A total of 179 581 patients with metastatic cancer were identified from the Swedish Cancer Registry and metastatic sites were identified using the Cause of Death Register and the National Patient Register. Patterns of metastatic spread were described across age and sex. In men, colorectal cancer was the main source of lung, peritoneal, and liver metastases. Lung cancer was the main origin of pleural and nervous system metastases. Prostate cancer dominated bone metastases but had minor contribution to other metastatic sites. Among women, breast cancer was the dominant origin of most metastatic sites, with the exception of peritoneum which was ruled by metastases from the ovary. As other exceptions, for nervous system metastases, lung cancer was the origin of metastases somewhat more frequently than breast cancer and for liver metastases, colorectal cancer was the main origin instead of breast cancer. The present achievement was to implement the first nationwide description of clinical landscape of cancer metastases, with an aim to serve as a reliable source for clinicians and researchers.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, database, epidemiology, metastasis, nationwide
in
Cancer Medicine
volume
7
issue
11
pages
5534 - 5542
publisher
Wiley-Blackwell
external identifiers
  • scopus:85055096831
ISSN
2045-7634
DOI
10.1002/cam4.1697
language
English
LU publication?
yes
id
99ce8368-98a5-456a-956c-808c5a9361b8
date added to LUP
2018-10-31 22:51:30
date last changed
2019-01-31 03:00:10
@article{99ce8368-98a5-456a-956c-808c5a9361b8,
  abstract     = {<p>Population-based data on metastatic patterns are lacking because cancer registries seldom record metastases. This study uses a novel population-based approach to identify metastases and describes metastatic pathways from 14 common primary cancers to 12 specific metastatic sites. A total of 179 581 patients with metastatic cancer were identified from the Swedish Cancer Registry and metastatic sites were identified using the Cause of Death Register and the National Patient Register. Patterns of metastatic spread were described across age and sex. In men, colorectal cancer was the main source of lung, peritoneal, and liver metastases. Lung cancer was the main origin of pleural and nervous system metastases. Prostate cancer dominated bone metastases but had minor contribution to other metastatic sites. Among women, breast cancer was the dominant origin of most metastatic sites, with the exception of peritoneum which was ruled by metastases from the ovary. As other exceptions, for nervous system metastases, lung cancer was the origin of metastases somewhat more frequently than breast cancer and for liver metastases, colorectal cancer was the main origin instead of breast cancer. The present achievement was to implement the first nationwide description of clinical landscape of cancer metastases, with an aim to serve as a reliable source for clinicians and researchers.</p>},
  author       = {Riihimäki, Matias and Thomsen, Hauke and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {2045-7634},
  keyword      = {cancer,database,epidemiology,metastasis,nationwide},
  language     = {eng},
  number       = {11},
  pages        = {5534--5542},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Medicine},
  title        = {Clinical landscape of cancer metastases},
  url          = {http://dx.doi.org/10.1002/cam4.1697},
  volume       = {7},
  year         = {2018},
}