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Spatial analysis of diffusion tensor tractography statistics along the inferior fronto-occipital fasciculus with application in progressive supranuclear palsy

Mårtensson, Johanna LU ; Nilsson, Markus LU ; Ståhlberg, Freddy LU ; Sundgren, Pia LU ; Nilsson, Christer LU ; van Westen, Danielle LU ; Larsson, Elna-Marie and Lätt, Jimmy LU (2013) In Magma 26(6). p.527-537
Abstract
The purpose of the study was to develop a method for analysis of diffusion parameters along white matter (WM) tracts, using spatial normalization based on anatomical landmarks, and to introduce the apparent area coefficient (AAC). The method's applicability was tested in the inferior fronto-occipital fasciculus (IFO) in patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). A framework for analysis of diffusion parameters was developed. Spatial normalization of the tracts was performed using anatomical landmarks, to avoid deformations caused by cerebral atrophy. Initially, 38 HCs were used to optimize a threshold for the minimal size of regions that differ between groups. The fractional anisotropy, mean diffusivity,... (More)
The purpose of the study was to develop a method for analysis of diffusion parameters along white matter (WM) tracts, using spatial normalization based on anatomical landmarks, and to introduce the apparent area coefficient (AAC). The method's applicability was tested in the inferior fronto-occipital fasciculus (IFO) in patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). A framework for analysis of diffusion parameters was developed. Spatial normalization of the tracts was performed using anatomical landmarks, to avoid deformations caused by cerebral atrophy. Initially, 38 HCs were used to optimize a threshold for the minimal size of regions that differ between groups. The fractional anisotropy, mean diffusivity, AAC, and the hemispheric asymmetry index (AI), were compared between 11 PSP patients and 15 HCs. The method was feasible for analysis of PSP patients and HCs. The AI showed that the observed hemispheric asymmetry of AAC was significantly larger in PSP patients compared with HCs in small regions of the IFO. The method was successfully employed for analysis of diffusion parameters along the IFO in a patient group. This method can be potentially useful in studies of WM diseases, with or without cerebral atrophy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DTI, Tractography, Inferior fronto-occipital fasciculus, PSP
in
Magma
volume
26
issue
6
pages
527 - 537
publisher
Springer
external identifiers
  • wos:000327438700003
  • scopus:84890428277
ISSN
1352-8661
DOI
10.1007/s10334-013-0368-5
language
English
LU publication?
yes
id
9b56f32e-a4fb-4bde-a56e-d597b3973272 (old id 4273376)
date added to LUP
2014-02-10 12:26:13
date last changed
2019-07-14 03:50:50
@article{9b56f32e-a4fb-4bde-a56e-d597b3973272,
  abstract     = {The purpose of the study was to develop a method for analysis of diffusion parameters along white matter (WM) tracts, using spatial normalization based on anatomical landmarks, and to introduce the apparent area coefficient (AAC). The method's applicability was tested in the inferior fronto-occipital fasciculus (IFO) in patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). A framework for analysis of diffusion parameters was developed. Spatial normalization of the tracts was performed using anatomical landmarks, to avoid deformations caused by cerebral atrophy. Initially, 38 HCs were used to optimize a threshold for the minimal size of regions that differ between groups. The fractional anisotropy, mean diffusivity, AAC, and the hemispheric asymmetry index (AI), were compared between 11 PSP patients and 15 HCs. The method was feasible for analysis of PSP patients and HCs. The AI showed that the observed hemispheric asymmetry of AAC was significantly larger in PSP patients compared with HCs in small regions of the IFO. The method was successfully employed for analysis of diffusion parameters along the IFO in a patient group. This method can be potentially useful in studies of WM diseases, with or without cerebral atrophy.},
  author       = {Mårtensson, Johanna and Nilsson, Markus and Ståhlberg, Freddy and Sundgren, Pia and Nilsson, Christer and van Westen, Danielle and Larsson, Elna-Marie and Lätt, Jimmy},
  issn         = {1352-8661},
  keyword      = {DTI,Tractography,Inferior fronto-occipital fasciculus,PSP},
  language     = {eng},
  number       = {6},
  pages        = {527--537},
  publisher    = {Springer},
  series       = {Magma},
  title        = {Spatial analysis of diffusion tensor tractography statistics along the inferior fronto-occipital fasciculus with application in progressive supranuclear palsy},
  url          = {http://dx.doi.org/10.1007/s10334-013-0368-5},
  volume       = {26},
  year         = {2013},
}