Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age
(2018) In Acta Paediatrica, International Journal of Paediatrics 107(5). p.811-821- Abstract
Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30... (More)
Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30 months. Results: We focused on 399 known extremely preterm survivors and compared them to 300 full-term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30-month cognitive and neuromotor development outcomes. Conclusion: This time-course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.
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- author
- Hellström, Ann LU ; Källén, Karin LU ; Carlsson, Birgitta ; Holmström, Gerd ; Jakobsson, Peter LU ; Lundgren, Pia ; Serenius, Fredrik ; Stjernqvist, Karin LU ; Tornqvist, Kristina LU and Hellgren, Kerstin
- organization
- publishing date
- 2018-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bronchopulmonary dysplasia, Intraventricular haemorrhage, Ophthalmological outcome, Perinatal risk factors, Retinopathy of prematurity
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 107
- issue
- 5
- pages
- 11 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:29281748
- scopus:85045467016
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.14206
- language
- English
- LU publication?
- yes
- id
- 9e7b6e5c-c353-4254-be37-4c49b49ded42
- date added to LUP
- 2018-04-23 13:35:37
- date last changed
- 2024-04-29 07:35:24
@article{9e7b6e5c-c353-4254-be37-4c49b49ded42,
abstract = {{<p>Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30 months. Results: We focused on 399 known extremely preterm survivors and compared them to 300 full-term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30-month cognitive and neuromotor development outcomes. Conclusion: This time-course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.</p>}},
author = {{Hellström, Ann and Källén, Karin and Carlsson, Birgitta and Holmström, Gerd and Jakobsson, Peter and Lundgren, Pia and Serenius, Fredrik and Stjernqvist, Karin and Tornqvist, Kristina and Hellgren, Kerstin}},
issn = {{0803-5253}},
keywords = {{Bronchopulmonary dysplasia; Intraventricular haemorrhage; Ophthalmological outcome; Perinatal risk factors; Retinopathy of prematurity}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{811--821}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age}},
url = {{http://dx.doi.org/10.1111/apa.14206}},
doi = {{10.1111/apa.14206}},
volume = {{107}},
year = {{2018}},
}