Advanced

Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age

Hellström, Ann LU ; Källén, Karin LU ; Carlsson, Birgitta; Holmström, Gerd; Jakobsson, Peter LU ; Lundgren, Pia; Serenius, Fredrik; Stjernqvist, Karin LU ; Tornqvist, Kristina LU and Hellgren, Kerstin (2018) In Acta Paediatrica, International Journal of Paediatrics 107(5). p.811-821
Abstract

Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30... (More)

Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30 months. Results: We focused on 399 known extremely preterm survivors and compared them to 300 full-term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30-month cognitive and neuromotor development outcomes. Conclusion: This time-course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bronchopulmonary dysplasia, Intraventricular haemorrhage, Ophthalmological outcome, Perinatal risk factors, Retinopathy of prematurity
in
Acta Paediatrica, International Journal of Paediatrics
volume
107
issue
5
pages
11 pages
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85045467016
ISSN
0803-5253
DOI
10.1111/apa.14206
language
English
LU publication?
yes
id
9e7b6e5c-c353-4254-be37-4c49b49ded42
date added to LUP
2018-04-23 13:35:37
date last changed
2019-10-15 06:36:15
@article{9e7b6e5c-c353-4254-be37-4c49b49ded42,
  abstract     = {<p>Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm. Methods: We carried out a prospective population-based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time-points from one minute after birth to 30 months. Results: We focused on 399 known extremely preterm survivors and compared them to 300 full-term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30-month cognitive and neuromotor development outcomes. Conclusion: This time-course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.</p>},
  author       = {Hellström, Ann and Källén, Karin and Carlsson, Birgitta and Holmström, Gerd and Jakobsson, Peter and Lundgren, Pia and Serenius, Fredrik and Stjernqvist, Karin and Tornqvist, Kristina and Hellgren, Kerstin},
  issn         = {0803-5253},
  keyword      = {Bronchopulmonary dysplasia,Intraventricular haemorrhage,Ophthalmological outcome,Perinatal risk factors,Retinopathy of prematurity},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {811--821},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age},
  url          = {http://dx.doi.org/10.1111/apa.14206},
  volume       = {107},
  year         = {2018},
}