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A Starch-and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin : A Randomized Controlled Study

Roth, Bodil LU ; Myllyvainio, Julia LU ; D’amato, Mauro ; Larsson, Ewa LU and Ohlsson, Bodil LU (2022) In Nutrients 14(9).
Abstract

Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy... (More)

Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy volunteers at baseline, whereas CCK and enkephalin levels were higher (p < 0.001). In the intervention group, total IBS-symptom severity score (IBS-SSS), specific gastrointestinal symptoms, psychological well-being, and the influence of intestinal symptoms on daily life were improved during the study, and weight decreased (p < 0.001 for all), whereas only constipation (p = 0.045) and bloating (p = 0.001) were improved in the control group. PAI-1 levels tended to be decreased in the intervention group (p = 0.066), with a difference in the decrease between groups (p = 0.022). Visfatin levels were decreased in the intervention group (p = 0.007). There were few correlations between hormonal levels and symptoms. Thus, this diet not only improves IBS symptoms but also seems to have a general health-promoting effect.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AXIN1, cholecystokinin (CCK), enkephalins, ghrelin, irritable bowel syndrome (IBS), plasminogen activator inhibitor-1 (PAI-1), starch-and sucrose-reduced diet (SSRD), visfatin
in
Nutrients
volume
14
issue
9
article number
1688
publisher
MDPI AG
external identifiers
  • scopus:85128342004
  • pmid:35565656
ISSN
2072-6643
DOI
10.3390/nu14091688
language
English
LU publication?
yes
id
9f3953f1-2b61-44d8-a7ea-b0c4d51c5fc9
date added to LUP
2022-06-20 15:55:22
date last changed
2024-06-25 02:38:01
@article{9f3953f1-2b61-44d8-a7ea-b0c4d51c5fc9,
  abstract     = {{<p>Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy volunteers at baseline, whereas CCK and enkephalin levels were higher (p &lt; 0.001). In the intervention group, total IBS-symptom severity score (IBS-SSS), specific gastrointestinal symptoms, psychological well-being, and the influence of intestinal symptoms on daily life were improved during the study, and weight decreased (p &lt; 0.001 for all), whereas only constipation (p = 0.045) and bloating (p = 0.001) were improved in the control group. PAI-1 levels tended to be decreased in the intervention group (p = 0.066), with a difference in the decrease between groups (p = 0.022). Visfatin levels were decreased in the intervention group (p = 0.007). There were few correlations between hormonal levels and symptoms. Thus, this diet not only improves IBS symptoms but also seems to have a general health-promoting effect.</p>}},
  author       = {{Roth, Bodil and Myllyvainio, Julia and D’amato, Mauro and Larsson, Ewa and Ohlsson, Bodil}},
  issn         = {{2072-6643}},
  keywords     = {{AXIN1; cholecystokinin (CCK); enkephalins; ghrelin; irritable bowel syndrome (IBS); plasminogen activator inhibitor-1 (PAI-1); starch-and sucrose-reduced diet (SSRD); visfatin}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{9}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{A Starch-and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin : A Randomized Controlled Study}},
  url          = {{http://dx.doi.org/10.3390/nu14091688}},
  doi          = {{10.3390/nu14091688}},
  volume       = {{14}},
  year         = {{2022}},
}