A Starch-and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin : A Randomized Controlled Study
(2022) In Nutrients 14(9).- Abstract
Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy... (More)
Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy volunteers at baseline, whereas CCK and enkephalin levels were higher (p < 0.001). In the intervention group, total IBS-symptom severity score (IBS-SSS), specific gastrointestinal symptoms, psychological well-being, and the influence of intestinal symptoms on daily life were improved during the study, and weight decreased (p < 0.001 for all), whereas only constipation (p = 0.045) and bloating (p = 0.001) were improved in the control group. PAI-1 levels tended to be decreased in the intervention group (p = 0.066), with a difference in the decrease between groups (p = 0.022). Visfatin levels were decreased in the intervention group (p = 0.007). There were few correlations between hormonal levels and symptoms. Thus, this diet not only improves IBS symptoms but also seems to have a general health-promoting effect.
(Less)
- author
- Roth, Bodil LU ; Myllyvainio, Julia LU ; D’amato, Mauro ; Larsson, Ewa LU and Ohlsson, Bodil LU
- organization
- publishing date
- 2022-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AXIN1, cholecystokinin (CCK), enkephalins, ghrelin, irritable bowel syndrome (IBS), plasminogen activator inhibitor-1 (PAI-1), starch-and sucrose-reduced diet (SSRD), visfatin
- in
- Nutrients
- volume
- 14
- issue
- 9
- article number
- 1688
- publisher
- MDPI AG
- external identifiers
-
- scopus:85128342004
- pmid:35565656
- ISSN
- 2072-6643
- DOI
- 10.3390/nu14091688
- language
- English
- LU publication?
- yes
- id
- 9f3953f1-2b61-44d8-a7ea-b0c4d51c5fc9
- date added to LUP
- 2022-06-20 15:55:22
- date last changed
- 2024-06-25 02:38:01
@article{9f3953f1-2b61-44d8-a7ea-b0c4d51c5fc9, abstract = {{<p>Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in IBS, conditions associated with plasminogen activator inhibitor-1 (PAI-1) and visfatin. The aim of this study was to measure blood levels of AXIN1, cholecystokinin (CCK), enkephalin, ghrelin, neuropeptide Y (NPY), PAI-1, and visfatin before and after a 4-week intervention with a starch-and sucrose-reduced diet (SSRD). A total of 105 IBS patients were randomized to either SSRD (n = 80) or ordinary diet (n = 25). Questionnaires were completed, and blood was analyzed for AXIN1 and hormones. AXIN1 (p = 0.001) and active ghrelin levels (p = 0.025) were lower in IBS than in healthy volunteers at baseline, whereas CCK and enkephalin levels were higher (p < 0.001). In the intervention group, total IBS-symptom severity score (IBS-SSS), specific gastrointestinal symptoms, psychological well-being, and the influence of intestinal symptoms on daily life were improved during the study, and weight decreased (p < 0.001 for all), whereas only constipation (p = 0.045) and bloating (p = 0.001) were improved in the control group. PAI-1 levels tended to be decreased in the intervention group (p = 0.066), with a difference in the decrease between groups (p = 0.022). Visfatin levels were decreased in the intervention group (p = 0.007). There were few correlations between hormonal levels and symptoms. Thus, this diet not only improves IBS symptoms but also seems to have a general health-promoting effect.</p>}}, author = {{Roth, Bodil and Myllyvainio, Julia and D’amato, Mauro and Larsson, Ewa and Ohlsson, Bodil}}, issn = {{2072-6643}}, keywords = {{AXIN1; cholecystokinin (CCK); enkephalins; ghrelin; irritable bowel syndrome (IBS); plasminogen activator inhibitor-1 (PAI-1); starch-and sucrose-reduced diet (SSRD); visfatin}}, language = {{eng}}, month = {{05}}, number = {{9}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{A Starch-and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin : A Randomized Controlled Study}}, url = {{http://dx.doi.org/10.3390/nu14091688}}, doi = {{10.3390/nu14091688}}, volume = {{14}}, year = {{2022}}, }