Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection
(2023) In JACC: Basic to Translational Science 8(5). p.439-456- Abstract
Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the extracellular vesicle-associated cytokine TWEAK to be elevated during ACR. Vesicular TWEAK promoted expression of proinflammatory genes and the release of chemoattractant cytokines from human cardiac endothelial cells. We conclude that vesicular TWEAK is a novel target with potential therapeutic implications in ACR.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a036bc1d-0da9-484b-a509-82ddbfe2f1d4
- author
- Celik, Selvi LU ; Sadrian, Julia ; Grossi, Mario LU ; Czuba, Tomasz LU ; Lundgren, Jakob LU ; Rådegran, Göran LU ; Laurell, Thomas LU ; Smith, J. Gustav and Gidlöf, Olof LU
- organization
-
- Molecular Epidemiology and Cardiology (research group)
- Cardiovascular Epigenetics (research group)
- Cardiology
- EXODIAB: Excellence of Diabetes Research in Sweden
- Lund Hemodynamic Lab (research group)
- Cardiopulmonary disease - information, support and reception (research group)
- LU Profile Area: Light and Materials
- LTH Profile Area: Nanoscience and Semiconductor Technology
- LTH Profile Area: Engineering Health
- LUCC: Lund University Cancer Centre
- Acoustofluidics group (research group)
- SEBRA Sepsis and Bacterial Resistance Alliance (research group)
- NanoLund: Centre for Nanoscience
- Department of Biomedical Engineering
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Molecular Cardiology (research group)
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute cellular rejection, chronic rejection, extracellular vesicle, TWEAK
- in
- JACC: Basic to Translational Science
- volume
- 8
- issue
- 5
- pages
- 18 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37325400
- scopus:85156236112
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2022.09.014
- language
- English
- LU publication?
- yes
- id
- a036bc1d-0da9-484b-a509-82ddbfe2f1d4
- date added to LUP
- 2023-08-16 12:48:59
- date last changed
- 2024-04-20 00:45:45
@article{a036bc1d-0da9-484b-a509-82ddbfe2f1d4,
abstract = {{<p>Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the extracellular vesicle-associated cytokine TWEAK to be elevated during ACR. Vesicular TWEAK promoted expression of proinflammatory genes and the release of chemoattractant cytokines from human cardiac endothelial cells. We conclude that vesicular TWEAK is a novel target with potential therapeutic implications in ACR.</p>}},
author = {{Celik, Selvi and Sadrian, Julia and Grossi, Mario and Czuba, Tomasz and Lundgren, Jakob and Rådegran, Göran and Laurell, Thomas and Smith, J. Gustav and Gidlöf, Olof}},
issn = {{2452-302X}},
keywords = {{acute cellular rejection; chronic rejection; extracellular vesicle; TWEAK}},
language = {{eng}},
number = {{5}},
pages = {{439--456}},
publisher = {{Elsevier}},
series = {{JACC: Basic to Translational Science}},
title = {{Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection}},
url = {{http://dx.doi.org/10.1016/j.jacbts.2022.09.014}},
doi = {{10.1016/j.jacbts.2022.09.014}},
volume = {{8}},
year = {{2023}},
}