Superinduction of cytokine gene transcription by ciprofloxacin
(1994) In Journal of Immunology 153(1). p.343-352- Abstract
In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1)... (More)
In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.
(Less)
- author
- Riesbeck, Kristian
LU
; Sigvardsson, Mikael LU ; Leanderson, Tomas LU and Forsgren, Arne LU
- organization
- publishing date
- 1994-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 153
- issue
- 1
- pages
- 343 - 352
- publisher
- American Association of Immunologists
- external identifiers
-
- scopus:0028283009
- pmid:8207247
- ISSN
- 0022-1767
- language
- English
- LU publication?
- yes
- id
- a1dac134-76fe-40f9-87d8-a75163897048
- alternative location
- http://www.jimmunol.org/content/153/1/343
- date added to LUP
- 2019-03-29 11:48:41
- date last changed
- 2024-02-14 20:52:33
@article{a1dac134-76fe-40f9-87d8-a75163897048, abstract = {{<p>In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.</p>}}, author = {{Riesbeck, Kristian and Sigvardsson, Mikael and Leanderson, Tomas and Forsgren, Arne}}, issn = {{0022-1767}}, language = {{eng}}, month = {{07}}, number = {{1}}, pages = {{343--352}}, publisher = {{American Association of Immunologists}}, series = {{Journal of Immunology}}, title = {{Superinduction of cytokine gene transcription by ciprofloxacin}}, url = {{http://www.jimmunol.org/content/153/1/343}}, volume = {{153}}, year = {{1994}}, }