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High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children

Lindberg, B LU ; Ericsson, U B; Ljung, R LU and Ivarsson, Sten LU (1997) In Journal of Laboratory and Clinical Medicine 130(6). p.585-589
Abstract

The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the... (More)

The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the diabetics versus 14% in the control group (p = 0.002), and thyroid peroxidase autoantibodies were positive in 38% versus 6% (p = 0.0001). The high prevalence of thyroid autoantibodies already at diagnosis stresses the importance of early screening for thyroid disease in patients with insulin-dependent diabetes mellitus.

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published
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keywords
Adolescent, Autoantibodies, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Iodide Peroxidase, Male, Sweden, Thyroglobulin, Thyroid Gland, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of Laboratory and Clinical Medicine
volume
130
issue
6
pages
5 pages
publisher
Academic Press
external identifiers
  • scopus:0031460546
ISSN
0022-2143
DOI
10.1016/S0022-2143(97)90108-6
language
English
LU publication?
yes
id
a4b3da03-957f-4c0b-828c-d647a2735027
date added to LUP
2016-12-29 13:31:20
date last changed
2017-07-30 05:19:38
@article{a4b3da03-957f-4c0b-828c-d647a2735027,
  abstract     = {<p>The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the diabetics versus 14% in the control group (p = 0.002), and thyroid peroxidase autoantibodies were positive in 38% versus 6% (p = 0.0001). The high prevalence of thyroid autoantibodies already at diagnosis stresses the importance of early screening for thyroid disease in patients with insulin-dependent diabetes mellitus.</p>},
  author       = {Lindberg, B and Ericsson, U B and Ljung, R and Ivarsson, Sten},
  issn         = {0022-2143},
  keyword      = {Adolescent,Autoantibodies,Child,Child, Preschool,Diabetes Mellitus, Type 1,Female,Humans,Iodide Peroxidase,Male,Sweden,Thyroglobulin,Thyroid Gland,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {6},
  pages        = {585--589},
  publisher    = {Academic Press},
  series       = {Journal of Laboratory and Clinical Medicine},
  title        = {High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children},
  url          = {http://dx.doi.org/10.1016/S0022-2143(97)90108-6},
  volume       = {130},
  year         = {1997},
}