High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children
Lindberg, B LU ; Ericsson, U B ; Ljung, R LU
and Ivarsson, Sten
LU
(1997)
In Journal of Laboratory and Clinical Medicine
130(6).
p.585-589
- Abstract
The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the... (More)
The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the diabetics versus 14% in the control group (p = 0.002), and thyroid peroxidase autoantibodies were positive in 38% versus 6% (p = 0.0001). The high prevalence of thyroid autoantibodies already at diagnosis stresses the importance of early screening for thyroid disease in patients with insulin-dependent diabetes mellitus.
(Less)
- author
- Lindberg, B
LU
; Ericsson, U B
; Ljung, R
LU
and Ivarsson, Sten
LU
- organization
- publishing date
- 1997-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Autoantibodies, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Iodide Peroxidase, Male, Sweden, Thyroglobulin, Thyroid Gland, Journal Article, Research Support, Non-U.S. Gov't
- in
- Journal of Laboratory and Clinical Medicine
- volume
- 130
- issue
- 6
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:9422332
- scopus:0031460546
- ISSN
- 0022-2143
- DOI
- 10.1016/S0022-2143(97)90108-6
- language
- English
- LU publication?
- yes
- id
- a4b3da03-957f-4c0b-828c-d647a2735027
- date added to LUP
- 2016-12-29 13:31:20
- date last changed
- 2024-01-04 19:59:09
@article{a4b3da03-957f-4c0b-828c-d647a2735027,
abstract = {{<p>The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radioassay for both thyroid autoantibodies, with comparable sensitivity, we found the prevalences of both autoantibodies to be higher in the insulin-dependent diabetes mellitus group than in the control group, the difference being most pronounced for thyroid peroxidase autoantibodies. Thyroglobulin autoantibodies were positive in 33% of the diabetics versus 14% in the control group (p = 0.002), and thyroid peroxidase autoantibodies were positive in 38% versus 6% (p = 0.0001). The high prevalence of thyroid autoantibodies already at diagnosis stresses the importance of early screening for thyroid disease in patients with insulin-dependent diabetes mellitus.</p>}},
author = {{Lindberg, B and Ericsson, U B and Ljung, R and Ivarsson, Sten}},
issn = {{0022-2143}},
keywords = {{Adolescent; Autoantibodies; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Iodide Peroxidase; Male; Sweden; Thyroglobulin; Thyroid Gland; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{6}},
pages = {{585--589}},
publisher = {{Elsevier}},
series = {{Journal of Laboratory and Clinical Medicine}},
title = {{High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children}},
url = {{http://dx.doi.org/10.1016/S0022-2143(97)90108-6}},
doi = {{10.1016/S0022-2143(97)90108-6}},
volume = {{130}},
year = {{1997}},
}