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Development and validation of a quantitative wipe sampling method to determine platinum contamination from antineoplastic drugs on surfaces in workplaces at Swedish hospitals

Leeman, Mats LU ; Wetterling, Maria ; Kåredal, Monica LU orcid and Hedmer, Maria LU orcid (2024) In Journal of oncology pharmacy practice
Abstract

INTRODUCTION: Antineoplastic drugs (ADs) are frequently used pharmaceuticals in the healthcare, and healthcare workers can be occupationally exposed to ADs. Monitoring of surface contamination is a common way to assess occupational exposure to ADs. The objective was to develop and validate a sensitive and quantitative monitoring method to determine surface contaminations of Pt as a marker for Pt-containing ADs. The surface contaminations of Pt-containing ADs were monitored at four Swedish hospital workplaces.

METHODS: An analytical method was developed based on inductively coupled plasma mass spectrometry. The wipe sampling procedure was validated regarding different surface materials. The stability of collected wipe samples was... (More)

INTRODUCTION: Antineoplastic drugs (ADs) are frequently used pharmaceuticals in the healthcare, and healthcare workers can be occupationally exposed to ADs. Monitoring of surface contamination is a common way to assess occupational exposure to ADs. The objective was to develop and validate a sensitive and quantitative monitoring method to determine surface contaminations of Pt as a marker for Pt-containing ADs. The surface contaminations of Pt-containing ADs were monitored at four Swedish hospital workplaces.

METHODS: An analytical method was developed based on inductively coupled plasma mass spectrometry. The wipe sampling procedure was validated regarding different surface materials. The stability of collected wipe samples was investigated. Workplace surfaces were monitored by wipe sampling to determine contaminations of Pt-containing ADs.

RESULTS: A wipe sampling and analytical method with a limit of detection of 0.1 pg Pt/cm
2 was developed. Pt was detected in 67% of the wipe samples collected from four workplaces, and the concentrations ranged from <0.10 to 21100 pg/cm
2. In 4% of samples, the detected surface contaminations of Pt in three hospital wards were above proposed hygienic guidance value (HGV) of Pt. In the hospital pharmacy, 9% of the detected surface contaminations of Pt were above lowest proposed HGV.

CONCLUSIONS: A user-friendly, specific, and sensitive method for determination of surface contaminations of Pt from ADs in work environments was developed and validated. A large variation of contaminations was observed between detected surface contaminations of Pt in samples collected in wards, and it likely reflects differences in amounts handled and work practices between the wards.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Journal of oncology pharmacy practice
article number
10781552241259405
publisher
SAGE Publications
external identifiers
  • scopus:85195296141
  • pmid:38835271
ISSN
1078-1552
DOI
10.1177/10781552241259405
language
English
LU publication?
yes
id
aa2794ff-cd72-4787-b3dc-5eb2d22208a7
date added to LUP
2024-06-12 12:59:33
date last changed
2024-06-13 04:00:06
@article{aa2794ff-cd72-4787-b3dc-5eb2d22208a7,
  abstract     = {{<p>INTRODUCTION: Antineoplastic drugs (ADs) are frequently used pharmaceuticals in the healthcare, and healthcare workers can be occupationally exposed to ADs. Monitoring of surface contamination is a common way to assess occupational exposure to ADs. The objective was to develop and validate a sensitive and quantitative monitoring method to determine surface contaminations of Pt as a marker for Pt-containing ADs. The surface contaminations of Pt-containing ADs were monitored at four Swedish hospital workplaces.</p><p>METHODS: An analytical method was developed based on inductively coupled plasma mass spectrometry. The wipe sampling procedure was validated regarding different surface materials. The stability of collected wipe samples was investigated. Workplace surfaces were monitored by wipe sampling to determine contaminations of Pt-containing ADs.</p><p>RESULTS: A wipe sampling and analytical method with a limit of detection of 0.1 pg Pt/cm<br>
 2 was developed. Pt was detected in 67% of the wipe samples collected from four workplaces, and the concentrations ranged from &lt;0.10 to 21100 pg/cm <br>
 2. In 4% of samples, the detected surface contaminations of Pt in three hospital wards were above proposed hygienic guidance value (HGV) of Pt. In the hospital pharmacy, 9% of the detected surface contaminations of Pt were above lowest proposed HGV.<br>
 </p><p>CONCLUSIONS: A user-friendly, specific, and sensitive method for determination of surface contaminations of Pt from ADs in work environments was developed and validated. A large variation of contaminations was observed between detected surface contaminations of Pt in samples collected in wards, and it likely reflects differences in amounts handled and work practices between the wards.</p>}},
  author       = {{Leeman, Mats and Wetterling, Maria and Kåredal, Monica and Hedmer, Maria}},
  issn         = {{1078-1552}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of oncology pharmacy practice}},
  title        = {{Development and validation of a quantitative wipe sampling method to determine platinum contamination from antineoplastic drugs on surfaces in workplaces at Swedish hospitals}},
  url          = {{http://dx.doi.org/10.1177/10781552241259405}},
  doi          = {{10.1177/10781552241259405}},
  year         = {{2024}},
}