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80-year-old men have elevated plasma concentrations of catecholamines but decreased plasma renin activity and aldosterone as compared to young men

Hallengren, B LU ; Elmståhl, S LU ; Galvard, H LU ; Jerntorp, P; Manhem, P LU ; Pessah-Rasmussen, H LU and Stavenow, L. (1992) In Aging (Milan, Italy)1989-01-01+01:002001-01-01+01:00 4(4). p.5-341
Abstract

Plasma concentrations of adrenaline, noradrenaline, aldosterone and plasma renin activity were determined in a selected group of 80-year-old men (N = 41) in good health without clinical signs of cardiovascular disease, and were compared to levels in young healthy males (N = 20, 24-28 years). Plasma adrenaline and noradrenaline concentrations were higher (0.24 median; 25th-75th percentiles 0.16-0.34 nmol/L vs 0.15; 0.11-0.18 nmol/L, p < 0.01 and 2.22; 1.58-3.27 nmol/L vs 1.15; 1.00-1.74 nmol/L, p < 0.001), and plasma renin activity and plasma aldosterone concentration were lower in the old than in the young men (0.65; 0.35-1.04 micrograms/L/1h vs 2.09; 1.23-2.41 micrograms/L/1h, p < 0.001 and 0.12; 0.09-0.19 nmol/L vs 0.38;... (More)

Plasma concentrations of adrenaline, noradrenaline, aldosterone and plasma renin activity were determined in a selected group of 80-year-old men (N = 41) in good health without clinical signs of cardiovascular disease, and were compared to levels in young healthy males (N = 20, 24-28 years). Plasma adrenaline and noradrenaline concentrations were higher (0.24 median; 25th-75th percentiles 0.16-0.34 nmol/L vs 0.15; 0.11-0.18 nmol/L, p < 0.01 and 2.22; 1.58-3.27 nmol/L vs 1.15; 1.00-1.74 nmol/L, p < 0.001), and plasma renin activity and plasma aldosterone concentration were lower in the old than in the young men (0.65; 0.35-1.04 micrograms/L/1h vs 2.09; 1.23-2.41 micrograms/L/1h, p < 0.001 and 0.12; 0.09-0.19 nmol/L vs 0.38; 0.28-0.54 nmol/L, p < 0.001). In conclusion, increased plasma concentrations of catecholamines and decreased plasma concentration of aldosterone and plasma renin activity in old men, as compared to young men, must be considered when interpreting data of these hormones in elderly men.

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published
subject
keywords
Adult, Aged, Aging, Aldosterone, Catecholamines, Epinephrine, Humans, Male, Norepinephrine, Reference Values, Renin, Comparative Study, Journal Article
in
Aging (Milan, Italy)1989-01-01+01:002001-01-01+01:00
volume
4
issue
4
pages
5 pages
publisher
Kurtis
external identifiers
  • scopus:0027095549
ISSN
0394-9532
language
English
LU publication?
yes
id
aadeaa90-bf5c-43ea-981a-b27f47613402
date added to LUP
2017-08-11 15:56:08
date last changed
2017-08-24 14:14:39
@article{aadeaa90-bf5c-43ea-981a-b27f47613402,
  abstract     = {<p>Plasma concentrations of adrenaline, noradrenaline, aldosterone and plasma renin activity were determined in a selected group of 80-year-old men (N = 41) in good health without clinical signs of cardiovascular disease, and were compared to levels in young healthy males (N = 20, 24-28 years). Plasma adrenaline and noradrenaline concentrations were higher (0.24 median; 25th-75th percentiles 0.16-0.34 nmol/L vs 0.15; 0.11-0.18 nmol/L, p &lt; 0.01 and 2.22; 1.58-3.27 nmol/L vs 1.15; 1.00-1.74 nmol/L, p &lt; 0.001), and plasma renin activity and plasma aldosterone concentration were lower in the old than in the young men (0.65; 0.35-1.04 micrograms/L/1h vs 2.09; 1.23-2.41 micrograms/L/1h, p &lt; 0.001 and 0.12; 0.09-0.19 nmol/L vs 0.38; 0.28-0.54 nmol/L, p &lt; 0.001). In conclusion, increased plasma concentrations of catecholamines and decreased plasma concentration of aldosterone and plasma renin activity in old men, as compared to young men, must be considered when interpreting data of these hormones in elderly men.</p>},
  author       = {Hallengren, B and Elmståhl, S and Galvard, H and Jerntorp, P and Manhem, P and Pessah-Rasmussen, H and Stavenow, L.},
  issn         = {0394-9532},
  keyword      = {Adult,Aged,Aging,Aldosterone,Catecholamines,Epinephrine,Humans,Male,Norepinephrine,Reference Values,Renin,Comparative Study,Journal Article},
  language     = {eng},
  number       = {4},
  pages        = {5--341},
  publisher    = {Kurtis},
  series       = {Aging (Milan, Italy)1989-01-01+01:002001-01-01+01:00},
  title        = {80-year-old men have elevated plasma concentrations of catecholamines but decreased plasma renin activity and aldosterone as compared to young men},
  volume       = {4},
  year         = {1992},
}