Expression Of Pten And Shp1, Investigated From Tissue Microarrays In Pediatric Acute Lymphoblastic, Leukemia
(2009) In Pediatric Hematology & Oncology 26(1). p.48-56- Abstract
- PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1374842
- author
- Gauffin, Fredrika ; Diffner, Eva LU ; Gustafsson, Bertil ; Nordgren, Ann ; Gjörloff Wingren, Anette LU ; Sander, Birgitta ; Persson, Jenny L LU and Gustafsson, Britt
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- SHP1, tissue microarray, pediatric leukemia, PTEN
- in
- Pediatric Hematology & Oncology
- volume
- 26
- issue
- 1
- pages
- 48 - 56
- publisher
- Hemisphere Pub. Corp.
- external identifiers
-
- wos:000263269000005
- scopus:61649117545
- ISSN
- 1521-0669
- DOI
- 10.1080/08880010802625530
- language
- English
- LU publication?
- yes
- additional info
- Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:32.
- id
- aafe346c-2383-4369-9e6b-f28879a303d5 (old id 1374842)
- date added to LUP
- 2016-04-01 11:40:21
- date last changed
- 2022-04-05 03:13:52
@article{aafe346c-2383-4369-9e6b-f28879a303d5, abstract = {{PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.}}, author = {{Gauffin, Fredrika and Diffner, Eva and Gustafsson, Bertil and Nordgren, Ann and Gjörloff Wingren, Anette and Sander, Birgitta and Persson, Jenny L and Gustafsson, Britt}}, issn = {{1521-0669}}, keywords = {{SHP1; tissue microarray; pediatric leukemia; PTEN}}, language = {{eng}}, number = {{1}}, pages = {{48--56}}, publisher = {{Hemisphere Pub. Corp.}}, series = {{Pediatric Hematology & Oncology}}, title = {{Expression Of Pten And Shp1, Investigated From Tissue Microarrays In Pediatric Acute Lymphoblastic, Leukemia}}, url = {{http://dx.doi.org/10.1080/08880010802625530}}, doi = {{10.1080/08880010802625530}}, volume = {{26}}, year = {{2009}}, }