Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Sud, Amit LU ; Chattopadhyay, Subhayan LU
; Thomsen, Hauke
LU
; Sundquist, Kristina
LU
; Sundquist, Jan
LU
; Houlston, Richard
and Hemminki, Kari
LU
(2019)
In Blood
134(12).
p.960-969
- Abstract
Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed... (More)
Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.
(Less)
- author
- Sud, Amit
LU
; Chattopadhyay, Subhayan
LU
; Thomsen, Hauke
LU
; Sundquist, Kristina
LU
; Sundquist, Jan
LU
; Houlston, Richard
and Hemminki, Kari
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 134
- issue
- 12
- pages
- 10 pages
- publisher
- American Society of Hematology
- external identifiers
-
- scopus:85072509380
- pmid:31395603
- ISSN
- 1528-0020
- DOI
- 10.1182/blood.2019001362
- language
- English
- LU publication?
- yes
- id
- abbfe67b-1f52-461d-a0d7-fc4ade2bd213
- date added to LUP
- 2019-08-26 08:22:53
- date last changed
- 2024-05-28 22:25:16
@article{abbfe67b-1f52-461d-a0d7-fc4ade2bd213,
abstract = {{<p>Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.</p>}},
author = {{Sud, Amit and Chattopadhyay, Subhayan and Thomsen, Hauke and Sundquist, Kristina and Sundquist, Jan and Houlston, Richard and Hemminki, Kari}},
issn = {{1528-0020}},
language = {{eng}},
number = {{12}},
pages = {{960--969}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk}},
url = {{http://dx.doi.org/10.1182/blood.2019001362}},
doi = {{10.1182/blood.2019001362}},
volume = {{134}},
year = {{2019}},
}