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Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk

Sud, Amit LU ; Chattopadhyay, Subhayan LU ; Thomsen, Hauke LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Houlston, Richard and Hemminki, Kari LU (2019) In Blood 134(12). p.960-969
Abstract

Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed... (More)

Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
134
issue
12
pages
10 pages
publisher
American Society of Hematology
external identifiers
  • scopus:85072509380
ISSN
1528-0020
DOI
10.1182/blood.2019001362
language
English
LU publication?
yes
id
abbfe67b-1f52-461d-a0d7-fc4ade2bd213
date added to LUP
2019-08-26 08:22:53
date last changed
2019-10-04 07:47:50
@article{abbfe67b-1f52-461d-a0d7-fc4ade2bd213,
  abstract     = {<p>Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.</p>},
  author       = {Sud, Amit and Chattopadhyay, Subhayan and Thomsen, Hauke and Sundquist, Kristina and Sundquist, Jan and Houlston, Richard and Hemminki, Kari},
  issn         = {1528-0020},
  language     = {eng},
  number       = {12},
  pages        = {960--969},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk},
  url          = {http://dx.doi.org/10.1182/blood.2019001362},
  volume       = {134},
  year         = {2019},
}