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Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Zamora-Ros, Raul; Ferrari, Pietro; Gonzalez, Carlos A.; Tjonneland, Anne; Olsen, Anja; Bredsdorff, Lea; Overvad, Kim; Touillaud, Marina; Perquier, Florence and Fagherazzi, Guy, et al. (2013) In Breast Cancer Research and Treatment 139(1). p.163-176
Abstract
Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards... (More)
Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors. (Less)
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keywords
Flavonoids, Lignans, Breast cancer, Hormone receptors, EPIC
in
Breast Cancer Research and Treatment
volume
139
issue
1
pages
163 - 176
publisher
Springer
external identifiers
  • wos:000318524600017
  • scopus:84877577240
ISSN
1573-7217
DOI
10.1007/s10549-013-2483-4
language
English
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yes
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ace5cd75-472a-4b3c-94b7-2b9fe7606244 (old id 3815387)
date added to LUP
2013-07-01 06:57:59
date last changed
2019-02-20 05:35:08
@article{ace5cd75-472a-4b3c-94b7-2b9fe7606244,
  abstract     = {Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.},
  author       = {Zamora-Ros, Raul and Ferrari, Pietro and Gonzalez, Carlos A. and Tjonneland, Anne and Olsen, Anja and Bredsdorff, Lea and Overvad, Kim and Touillaud, Marina and Perquier, Florence and Fagherazzi, Guy and Lukanova, Annekatrin and Tikk, Kaja and Aleksandrova, Krasimira and Boeing, Heiner and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Dilis, Vardis and Masala, Giovanna and Sieri, Sabina and Mattiello, Amalia and Tumino, Rosario and Ricceri, Fulvio and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Weiderpass, Elisabete and Skeie, Guri and Engeset, Dagrun and Menendez, Virginia and Travier, Noemie and Molina-Montes, Esther and Amiano, Pilar and Chirlaque, Maria-Dolores and Barricarte, Aurelio and Wallström, Peter and Sonestedt, Emily and Sund, Malin and Landberg, Rikard and Khaw, Kay-Thee and Wareham, Nicholas J. and Travis, Ruth C. and Scalbert, Augustin and Ward, Heather A. and Riboli, Elio and Romieu, Isabelle},
  issn         = {1573-7217},
  keyword      = {Flavonoids,Lignans,Breast cancer,Hormone receptors,EPIC},
  language     = {eng},
  number       = {1},
  pages        = {163--176},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study},
  url          = {http://dx.doi.org/10.1007/s10549-013-2483-4},
  volume       = {139},
  year         = {2013},
}