Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
(2012) In Diabetologia- Abstract
- AIMS/HYPOTHESIS: Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy. METHODS: We performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (n = 272) and Västerbotten (n = 100). Age- and sex-matched patients with type 2 diabetes were included as controls. Data on the use of oral hypoglycaemic agents (OHAs), insulin and insulin-OHA combination therapy was retrieved from the medical records. Poor glycaemic control was defined as HbA(1c) ≥7.0% (≥53 mmol/mol) at follow-up. RESULTS: The... (More)
- AIMS/HYPOTHESIS: Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy. METHODS: We performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (n = 272) and Västerbotten (n = 100). Age- and sex-matched patients with type 2 diabetes were included as controls. Data on the use of oral hypoglycaemic agents (OHAs), insulin and insulin-OHA combination therapy was retrieved from the medical records. Poor glycaemic control was defined as HbA(1c) ≥7.0% (≥53 mmol/mol) at follow-up. RESULTS: The individuals with LADA and with type 2 diabetes were followed for an average of 107 months. LADA patients were leaner than type 2 diabetes patients at diagnosis (BMI 27.7 vs 31.0 kg/m(2); p < 0.001) and follow-up (BMI 27.9 vs 30.2 kg/m(2); p < 0.001). Patients with LADA had been treated with insulin for longer than those with type 2 diabetes (53.3 vs 28.8 months; p < 0.001). There was no significant difference between the patient groups with regard to poor glycaemic control at diagnosis, but more patients with LADA (67.8%) than type 2 diabetes patients (53.0%; p < 0.001) had poor glycaemic control at follow-up. Patients with LADA had worse glycaemic control at follow-up compared with participants with type 2 diabetes (OR = 1.8, 95% CI 1.2, 2.7), adjusted for age at diagnosis, HbA(1c), BMI at diagnosis, follow-up time and duration of insulin treatment. CONCLUSIONS/INTERPRETATION: Individuals with LADA have worse glycaemic control than patients with type 2 diabetes despite a longer time on insulin therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160363
- author
- Andersen, Caroline LU ; Bennet, Louise LU ; Nyström, L ; Lindblad, Ulf LU ; Lindholm, Eero LU ; Groop, Leif LU and Rolandsson, O
- organization
-
- Community Medicine (research group)
- Family Medicine and Community Medicine (research group)
- Family Medicine, Cardiovascular Epidemiology and Lifestyle (research group)
- Translational Muscle Research (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- publisher
- Springer
- external identifiers
-
- wos:000313075500004
- pmid:23096095
- scopus:84878777575
- pmid:23096095
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-012-2759-y
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Faculty of Medicine (000022000), Diabetes and Endocrinology (013241530), Community Medicine (013241810), Family medicine, cardiovascular epidemiology and lifestyle (013240038), Family Medicine (013241010)
- id
- aef07a13-5ab1-48d3-971d-d6953510582a (old id 3160363)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23096095?dopt=Abstract
- date added to LUP
- 2016-04-04 07:11:03
- date last changed
- 2024-02-27 15:37:06
@article{aef07a13-5ab1-48d3-971d-d6953510582a, abstract = {{AIMS/HYPOTHESIS: Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy. METHODS: We performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (n = 272) and Västerbotten (n = 100). Age- and sex-matched patients with type 2 diabetes were included as controls. Data on the use of oral hypoglycaemic agents (OHAs), insulin and insulin-OHA combination therapy was retrieved from the medical records. Poor glycaemic control was defined as HbA(1c) ≥7.0% (≥53 mmol/mol) at follow-up. RESULTS: The individuals with LADA and with type 2 diabetes were followed for an average of 107 months. LADA patients were leaner than type 2 diabetes patients at diagnosis (BMI 27.7 vs 31.0 kg/m(2); p < 0.001) and follow-up (BMI 27.9 vs 30.2 kg/m(2); p < 0.001). Patients with LADA had been treated with insulin for longer than those with type 2 diabetes (53.3 vs 28.8 months; p < 0.001). There was no significant difference between the patient groups with regard to poor glycaemic control at diagnosis, but more patients with LADA (67.8%) than type 2 diabetes patients (53.0%; p < 0.001) had poor glycaemic control at follow-up. Patients with LADA had worse glycaemic control at follow-up compared with participants with type 2 diabetes (OR = 1.8, 95% CI 1.2, 2.7), adjusted for age at diagnosis, HbA(1c), BMI at diagnosis, follow-up time and duration of insulin treatment. CONCLUSIONS/INTERPRETATION: Individuals with LADA have worse glycaemic control than patients with type 2 diabetes despite a longer time on insulin therapy.}}, author = {{Andersen, Caroline and Bennet, Louise and Nyström, L and Lindblad, Ulf and Lindholm, Eero and Groop, Leif and Rolandsson, O}}, issn = {{1432-0428}}, language = {{eng}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.}}, url = {{http://dx.doi.org/10.1007/s00125-012-2759-y}}, doi = {{10.1007/s00125-012-2759-y}}, year = {{2012}}, }