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Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat

Bauer, H G; Asp, N G LU ; Dahlqvist, A; Fredlund, P E; Nyman, M LU and Oste, R (1981) In Cancer Research 41(6). p.23-2518
Abstract

The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Adenocarcinoma/chemically induced, Animals, Bacteria/enzymology, Body Weight, Cellulose/pharmacology, Colonic Neoplasms/chemically induced, Dietary Fiber/pharmacology, Dimethylhydrazines/toxicity, Feces/analysis, Glucuronidase/metabolism, Male, Methylhydrazines/toxicity, Pectins/pharmacology, Rats
in
Cancer Research
volume
41
issue
6
pages
6 pages
publisher
American Association for Cancer Research Inc.
external identifiers
  • scopus:0019427281
ISSN
0008-5472
language
English
LU publication?
yes
id
afe92857-c4cc-447e-8508-42a4a0c50278
alternative location
http://cancerres.aacrjournals.org/content/canres/41/6/2518.full.pdf
date added to LUP
2018-10-16 18:22:31
date last changed
2018-10-29 21:15:01
@article{afe92857-c4cc-447e-8508-42a4a0c50278,
  abstract     = {<p>The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.</p>},
  author       = {Bauer, H G and Asp, N G and Dahlqvist, A and Fredlund, P E and Nyman, M and Oste, R},
  issn         = {0008-5472},
  keyword      = {Adenocarcinoma/chemically induced,Animals,Bacteria/enzymology,Body Weight,Cellulose/pharmacology,Colonic Neoplasms/chemically induced,Dietary Fiber/pharmacology,Dimethylhydrazines/toxicity,Feces/analysis,Glucuronidase/metabolism,Male,Methylhydrazines/toxicity,Pectins/pharmacology,Rats},
  language     = {eng},
  number       = {6},
  pages        = {23--2518},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat},
  volume       = {41},
  year         = {1981},
}