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Potato consumption and risk of pancreatic cancer in the HELGA cohort

Åsli, Lene A.; Braaten, Tonje; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Nilsson, Lena Maria; Renström, Frida LU ; Lund, Eiliv and Skeie, Guri (2018) In British Journal of Nutrition 119(12). p.1408-1415
Abstract

Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ's), lifestyle and health was collected by means of a questionnaire, and 221... (More)

Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ's), lifestyle and health was collected by means of a questionnaire, and 221 pancreatic cancer cases were identified through cancer registries. The mean follow-up time was 11·4 (95 % CI 0·3, 16·9) years. High consumption of potatoes showed a non-significantly higher risk of pancreatic cancer in the adjusted model (hazard ratio (HR) 1·44; 95 % CI 0·93, 2·22, P for trend 0·030) when comparing the highest v. The lowest quartile of potato consumption. In the sex-specific analyses, significant associations were found for females (HR 2·00; 95 % CI 1·07, 3·72, P for trend 0·020), but not for males (HR 1·01; 95 % CI 0·56, 1·84, P for trend 0·34). In addition, we explored the associations by spline regression, and the absence of dose-response effects was confirmed. In this study, high potato consumption was not consistently associated with a higher risk of pancreatic cancer. Further studies with larger populations are needed to explore the possible sex difference.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Cancer, Cohort studies, Epidemiology, Potatoes
in
British Journal of Nutrition
volume
119
issue
12
pages
8 pages
publisher
Cambridge University Press
external identifiers
  • scopus:85047946429
ISSN
0007-1145
DOI
language
English
LU publication?
yes
id
b08dd1c5-b67a-4752-a62f-31d23a1f2a6b
date added to LUP
2018-06-11 11:25:38
date last changed
2018-06-12 03:00:03
@article{b08dd1c5-b67a-4752-a62f-31d23a1f2a6b,
  abstract     = {<p>Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ's), lifestyle and health was collected by means of a questionnaire, and 221 pancreatic cancer cases were identified through cancer registries. The mean follow-up time was 11·4 (95 % CI 0·3, 16·9) years. High consumption of potatoes showed a non-significantly higher risk of pancreatic cancer in the adjusted model (hazard ratio (HR) 1·44; 95 % CI 0·93, 2·22, P for trend 0·030) when comparing the highest v. The lowest quartile of potato consumption. In the sex-specific analyses, significant associations were found for females (HR 2·00; 95 % CI 1·07, 3·72, P for trend 0·020), but not for males (HR 1·01; 95 % CI 0·56, 1·84, P for trend 0·34). In addition, we explored the associations by spline regression, and the absence of dose-response effects was confirmed. In this study, high potato consumption was not consistently associated with a higher risk of pancreatic cancer. Further studies with larger populations are needed to explore the possible sex difference.</p>},
  author       = {Åsli, Lene A. and Braaten, Tonje and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Nilsson, Lena Maria and Renström, Frida and Lund, Eiliv and Skeie, Guri},
  issn         = {0007-1145},
  keyword      = {Cancer,Cohort studies,Epidemiology,Potatoes},
  language     = {eng},
  month        = {06},
  number       = {12},
  pages        = {1408--1415},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Potato consumption and risk of pancreatic cancer in the HELGA cohort},
  url          = {http://dx.doi.org/},
  volume       = {119},
  year         = {2018},
}