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The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Rewers, Marian ; Lernmark, Åke LU orcid ; Agardh, Daniel LU ; Almgren, Peter LU ; Andrén Aronsson, Carin LU orcid ; Ask, Maria LU ; Carlsson, Ulla-Marie LU ; Cilio, Corrado LU ; Bremer, Jenny LU and Gerardsson, Joanna LU , et al. (2008) In Annals of the New York Academy of Sciences 1150. p.1-13
Abstract

The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in... (More)

The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.

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contributor
Oberste, Steve
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Autoantibodies/analysis, Child, Child, Preschool, Diabetes Mellitus, Type 1/epidemiology, Environment, Follow-Up Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Immunologic Techniques/standards, Infant, Mass Screening, Prevalence, Risk Factors
in
Annals of the New York Academy of Sciences
volume
1150
pages
1 - 13
publisher
Wiley-Blackwell
external identifiers
  • pmid:19120261
  • scopus:57749178141
ISSN
0077-8923
DOI
10.1196/annals.1447.062
language
English
LU publication?
yes
id
b62c1a2d-d812-47fa-8c9c-f3e9c5cfe389
date added to LUP
2021-10-14 15:29:43
date last changed
2024-04-06 11:44:34
@article{b62c1a2d-d812-47fa-8c9c-f3e9c5cfe389,
  abstract     = {{<p>The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.</p>}},
  author       = {{Rewers, Marian and Lernmark, Åke and Agardh, Daniel and Almgren, Peter and Andrén Aronsson, Carin and Ask, Maria and Carlsson, Ulla-Marie and Cilio, Corrado and Bremer, Jenny and Gerardsson, Joanna and Gustavsson, Barbro and Hansson, Gertie and Jönsson, Ida and Hansen, Monica and Hyberg, Susanne and Ivarsson, Sten and Larsson, Helena and Lernmark, Barbro and Markan, Maria and Melin, Marie Jessica and Månsson Martinez, Maria and Rahmati, Kobra and Sedig-Järvirova, Monica and Sjöberg, Birgitta and Törn, Carina and Wallin, Anne and Wigheden, Ingrid and Wimar, Åsa}},
  issn         = {{0077-8923}},
  keywords     = {{Adolescent; Autoantibodies/analysis; Child; Child, Preschool; Diabetes Mellitus, Type 1/epidemiology; Environment; Follow-Up Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Immunologic Techniques/standards; Infant; Mass Screening; Prevalence; Risk Factors}},
  language     = {{eng}},
  pages        = {{1--13}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of the New York Academy of Sciences}},
  title        = {{The Environmental Determinants of Diabetes in the Young (TEDDY) Study}},
  url          = {{http://dx.doi.org/10.1196/annals.1447.062}},
  doi          = {{10.1196/annals.1447.062}},
  volume       = {{1150}},
  year         = {{2008}},
}