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Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Zetterqvist, Anna LU ; Berglund, Lisa LU ; Blanco, Fabiana LU ; Garcia Vaz, Eliana LU ; Wigren, Maria LU ; Dunér, Pontus LU ; Dutius Andersson, Anna-Maria LU ; To, Fong LU ; Spégel, Peter LU and Nilsson, Jan LU , et al. (2013) In PLoS ONE 8(6).
Abstract
Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.
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Contribution to journal
publication status
published
subject
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PLoS ONE
volume
8
issue
6
publisher
Public Library of Science
external identifiers
  • wos:000319872300042
  • pmid:23755169
  • scopus:84878655746
ISSN
1932-6203
DOI
10.1371/journal.pone.0065020
language
English
LU publication?
yes
id
b72bd34a-f17f-40ee-bc0a-1767c9a10e7d (old id 3913480)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23755169?dopt=Abstract
date added to LUP
2013-07-01 12:38:23
date last changed
2019-05-28 01:56:04
@article{b72bd34a-f17f-40ee-bc0a-1767c9a10e7d,
  abstract     = {Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.},
  articleno    = {e65020},
  author       = {Zetterqvist, Anna and Berglund, Lisa and Blanco, Fabiana and Garcia Vaz, Eliana and Wigren, Maria and Dunér, Pontus and Dutius Andersson, Anna-Maria and To, Fong and Spégel, Peter and Nilsson, Jan and Bengtsson, Eva and Gomez, Maria},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0065020},
  volume       = {8},
  year         = {2013},
}