Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden

Li, Xinjun LU ; Thomsen, Hauke LU orcid ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU and Hemminki, Kari LU (2021) In Autoimmune Diseases 2021.
Abstract

Background. Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients. Methods. We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks.... (More)

Background. Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients. Methods. We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks. Results. The number of PA patients in the offspring generation (for which the familial risk was calculated) was 7701; 278 (3.6%) patients had a family history of PA. The population prevalence of PA was 0.9/1000. The familial risk for PA was 3.88 when any first-degree relative was the proband, equal for men and women. The familial risk was two times higher between siblings than between offspring and parents which may be due to complex genetic background. Associations of PA with 14 discordant AIDs were significant; these included some AIDs that have previously been described as comorbidities in PA patients and several yet unreported associations, including rheumatoid arthritis and other AIDs. Conclusions. The familial risks for PA were high suggesting multifactorial genetic etiology. The results call for further population-level studies to unravel mechanisms of familial PA which may help to understand the etiology of this disease.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Autoimmune Diseases
volume
2021
article number
8815297
publisher
Hindawi Limited
external identifiers
  • pmid:33505716
  • scopus:85099965595
ISSN
2090-0422
DOI
10.1155/2021/8815297
language
English
LU publication?
yes
id
b7c522fc-24e7-45f0-8637-5db7741b6968
date added to LUP
2021-02-10 06:48:03
date last changed
2024-04-18 01:53:02
@article{b7c522fc-24e7-45f0-8637-5db7741b6968,
  abstract     = {{<p>Background. Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients. Methods. We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks. Results. The number of PA patients in the offspring generation (for which the familial risk was calculated) was 7701; 278 (3.6%) patients had a family history of PA. The population prevalence of PA was 0.9/1000. The familial risk for PA was 3.88 when any first-degree relative was the proband, equal for men and women. The familial risk was two times higher between siblings than between offspring and parents which may be due to complex genetic background. Associations of PA with 14 discordant AIDs were significant; these included some AIDs that have previously been described as comorbidities in PA patients and several yet unreported associations, including rheumatoid arthritis and other AIDs. Conclusions. The familial risks for PA were high suggesting multifactorial genetic etiology. The results call for further population-level studies to unravel mechanisms of familial PA which may help to understand the etiology of this disease. </p>}},
  author       = {{Li, Xinjun and Thomsen, Hauke and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Kari}},
  issn         = {{2090-0422}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{Autoimmune Diseases}},
  title        = {{Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden}},
  url          = {{http://dx.doi.org/10.1155/2021/8815297}},
  doi          = {{10.1155/2021/8815297}},
  volume       = {{2021}},
  year         = {{2021}},
}