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Lifestyle and dietary determinants of serum apolipoprotein A1 and apolipoprotein B concentrations : Cross-sectional analyses within a Swedish Cohort of 24,984 individuals

Frondelius, Kasper ; Borg, Madelene ; Ericson, Ulrika LU ; Borné, Yan LU ; Melander, Olle LU orcid and Sonestedt, Emily LU orcid (2017) In Nutrients 9(3).
Abstract

Low serum apolipoprotein (Apo) A1 concentrations and high serum ApoB concentrations may be better markers of the risk of cardiovascular disease than high-density lipoprotein (HDL) and low-density lipoprotein (LDL). However, the associations between modifiable lifestyle factors and Apo concentrations have not been investigated in detail. Therefore, this study investigated the associations between Apo concentrations and education, lifestyle factors and dietary intake (macronutrients and 34 food groups). These cross-sectional associations were examined among 24,984 individuals in a Swedish population-based cohort. Baseline examinations of the cohort were conducted between 1991 and 1996. Dietary intake was assessed using a modified diet... (More)

Low serum apolipoprotein (Apo) A1 concentrations and high serum ApoB concentrations may be better markers of the risk of cardiovascular disease than high-density lipoprotein (HDL) and low-density lipoprotein (LDL). However, the associations between modifiable lifestyle factors and Apo concentrations have not been investigated in detail. Therefore, this study investigated the associations between Apo concentrations and education, lifestyle factors and dietary intake (macronutrients and 34 food groups). These cross-sectional associations were examined among 24,984 individuals in a Swedish population-based cohort. Baseline examinations of the cohort were conducted between 1991 and 1996. Dietary intake was assessed using a modified diet history method. The main determinants of high ApoA1 concentrations (r between 0.05 and 0.25) were high alcohol consumption, high physical activity, non-smoking, and a low body mass index (BMI), and the main determinants of high ApoB concentrations were smoking and a high BMI. The intake of sucrose and food products containing added sugar (such as pastries, sweets, chocolate, jam/sugar and sugar-sweetened beverages) was negatively correlated with ApoA1 concentrations and positively correlated with ApoB concentrations and the ApoB/ApoA1 ratio, whereas the intake of fermented dairy products, such as fermented milk and cheese, was positively correlated with ApoA1 concentrations and negatively correlated with the ApoB/ApoA1 ratio. These results indicate that smoking, obesity, low physical activity, low alcohol consumption and a diet high in sugar and low in fermented dairy products are correlated with an unfavorable Apo profile.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apolipoproteins, Diet, Epidemiology, Nutrition
in
Nutrients
volume
9
issue
3
article number
211
publisher
MDPI AG
external identifiers
  • scopus:85014361861
  • pmid:28264492
  • wos:000397023600030
ISSN
2072-6643
DOI
10.3390/nu9030211
language
English
LU publication?
yes
id
b9c4d77e-ad13-4011-83aa-ca4a636e4717
date added to LUP
2017-03-15 07:22:00
date last changed
2024-06-24 17:26:46
@article{b9c4d77e-ad13-4011-83aa-ca4a636e4717,
  abstract     = {{<p>Low serum apolipoprotein (Apo) A1 concentrations and high serum ApoB concentrations may be better markers of the risk of cardiovascular disease than high-density lipoprotein (HDL) and low-density lipoprotein (LDL). However, the associations between modifiable lifestyle factors and Apo concentrations have not been investigated in detail. Therefore, this study investigated the associations between Apo concentrations and education, lifestyle factors and dietary intake (macronutrients and 34 food groups). These cross-sectional associations were examined among 24,984 individuals in a Swedish population-based cohort. Baseline examinations of the cohort were conducted between 1991 and 1996. Dietary intake was assessed using a modified diet history method. The main determinants of high ApoA1 concentrations (r between 0.05 and 0.25) were high alcohol consumption, high physical activity, non-smoking, and a low body mass index (BMI), and the main determinants of high ApoB concentrations were smoking and a high BMI. The intake of sucrose and food products containing added sugar (such as pastries, sweets, chocolate, jam/sugar and sugar-sweetened beverages) was negatively correlated with ApoA1 concentrations and positively correlated with ApoB concentrations and the ApoB/ApoA1 ratio, whereas the intake of fermented dairy products, such as fermented milk and cheese, was positively correlated with ApoA1 concentrations and negatively correlated with the ApoB/ApoA1 ratio. These results indicate that smoking, obesity, low physical activity, low alcohol consumption and a diet high in sugar and low in fermented dairy products are correlated with an unfavorable Apo profile.</p>}},
  author       = {{Frondelius, Kasper and Borg, Madelene and Ericson, Ulrika and Borné, Yan and Melander, Olle and Sonestedt, Emily}},
  issn         = {{2072-6643}},
  keywords     = {{Apolipoproteins; Diet; Epidemiology; Nutrition}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Lifestyle and dietary determinants of serum apolipoprotein A1 and apolipoprotein B concentrations : Cross-sectional analyses within a Swedish Cohort of 24,984 individuals}},
  url          = {{http://dx.doi.org/10.3390/nu9030211}},
  doi          = {{10.3390/nu9030211}},
  volume       = {{9}},
  year         = {{2017}},
}