The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes
(2017) In PLoS ONE 12(6).- Abstract
To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in... (More)
To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in individuals with recent onset type 1 diabetes. The reduced density of parasympathetic axons in the exocrine compartment could have functional implications, e.g. be related to the exocrine insufficiency reported in type 1 diabetes patients. Further studies are needed to understand whether reduced parasympathetic innervation is a cause or consequence of type 1 diabetes.
(Less)
- author
- Lundberg, Marcus ; Lindqvist, Andreas LU ; Wierup, Nils LU ; Krogvold, Lars ; Dahl-Jørgensen, Knut and Skog, Oskar
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 12
- issue
- 6
- article number
- e0179911
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85020910149
- pmid:28628651
- wos:000404043100049
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0179911
- language
- English
- LU publication?
- yes
- id
- bb97aaef-b109-4564-9754-eb86e06e4867
- date added to LUP
- 2017-07-28 13:09:26
- date last changed
- 2024-02-29 19:02:06
@article{bb97aaef-b109-4564-9754-eb86e06e4867,
abstract = {{<p>To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in individuals with recent onset type 1 diabetes. The reduced density of parasympathetic axons in the exocrine compartment could have functional implications, e.g. be related to the exocrine insufficiency reported in type 1 diabetes patients. Further studies are needed to understand whether reduced parasympathetic innervation is a cause or consequence of type 1 diabetes.</p>}},
author = {{Lundberg, Marcus and Lindqvist, Andreas and Wierup, Nils and Krogvold, Lars and Dahl-Jørgensen, Knut and Skog, Oskar}},
issn = {{1932-6203}},
language = {{eng}},
number = {{6}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes}},
url = {{http://dx.doi.org/10.1371/journal.pone.0179911}},
doi = {{10.1371/journal.pone.0179911}},
volume = {{12}},
year = {{2017}},
}