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Cross-linked N-telopeptide of type I collagen (NTx) in urine as a predictor of periprosthetic osteolysis.

von Schewelov, Thord LU ; Carlsson, Åke LU and Dahlberg, Leif LU (2006) In Journal of Orthopaedic Research 24(7). p.1342-1348
Abstract
Periprosthetic osteolysis is often nonsymptomatic and hard to visualize by conventional radiography. Cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast mediated bone resorption, has been suggested to evaluate local particulate-induced osteolysis in patients operated on with a total hip prosthesis. Urine specimens were sampled after hip joint replacement in 160 patients. NTx was analyzed by a commercially available ELISA kit. Osteolysis was identified in the acetabulum and confirmed at operation. Using analysis of covariance to correct for differences in age, gender, and time after operation, NTx (mean SD) was 36 +/- 12 BCE/nM creatinine in patients with osteolysis (n = 33) and 27 +/- 13 BCE/nM creatinine in... (More)
Periprosthetic osteolysis is often nonsymptomatic and hard to visualize by conventional radiography. Cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast mediated bone resorption, has been suggested to evaluate local particulate-induced osteolysis in patients operated on with a total hip prosthesis. Urine specimens were sampled after hip joint replacement in 160 patients. NTx was analyzed by a commercially available ELISA kit. Osteolysis was identified in the acetabulum and confirmed at operation. Using analysis of covariance to correct for differences in age, gender, and time after operation, NTx (mean SD) was 36 +/- 12 BCE/nM creatinine in patients with osteolysis (n = 33) and 27 +/- 13 BCE/nM creatinine in patients without osteolysis (n = 127) (p = 0.003). Eighteen hips of 38 (47%), demonstrating an annual wear of more than 0.2 mm and an NTx value above 29 BCE/nM creatinine, had been revised due to osteolysis. The osteolysis prevalence in this group was increased 10 times (CI 4-23, p < 0.05). Indeed, NTx release and annual wear were both associated with increased prevalence of osteolysis, however, independently of each other. NTx seems a feasible marker of periprosthetic osteolysis. A preoperative baseline NTx level is likely needed for its use as a predictor of periprosthetic osteolysis in individual cases. (c) 2006 Orthopaedic Research Society. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
collagen (NTx), bone turnover markers, osteolysis, total hip arthroplasty, cross-linked N-telopeptide of type I
in
Journal of Orthopaedic Research
volume
24
issue
7
pages
1342 - 1348
publisher
John Wiley & Sons
external identifiers
  • wos:000238700600003
  • pmid:16718682
  • scopus:33746156170
ISSN
1554-527X
DOI
10.1002/jor.20152
language
English
LU publication?
yes
id
bef5891f-e682-478d-9ede-fa9f957b9fd2 (old id 156611)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16718682&dopt=Abstract
date added to LUP
2007-07-30 12:08:48
date last changed
2019-01-06 06:05:39
@article{bef5891f-e682-478d-9ede-fa9f957b9fd2,
  abstract     = {Periprosthetic osteolysis is often nonsymptomatic and hard to visualize by conventional radiography. Cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast mediated bone resorption, has been suggested to evaluate local particulate-induced osteolysis in patients operated on with a total hip prosthesis. Urine specimens were sampled after hip joint replacement in 160 patients. NTx was analyzed by a commercially available ELISA kit. Osteolysis was identified in the acetabulum and confirmed at operation. Using analysis of covariance to correct for differences in age, gender, and time after operation, NTx (mean SD) was 36 +/- 12 BCE/nM creatinine in patients with osteolysis (n = 33) and 27 +/- 13 BCE/nM creatinine in patients without osteolysis (n = 127) (p = 0.003). Eighteen hips of 38 (47%), demonstrating an annual wear of more than 0.2 mm and an NTx value above 29 BCE/nM creatinine, had been revised due to osteolysis. The osteolysis prevalence in this group was increased 10 times (CI 4-23, p &lt; 0.05). Indeed, NTx release and annual wear were both associated with increased prevalence of osteolysis, however, independently of each other. NTx seems a feasible marker of periprosthetic osteolysis. A preoperative baseline NTx level is likely needed for its use as a predictor of periprosthetic osteolysis in individual cases. (c) 2006 Orthopaedic Research Society.},
  author       = {von Schewelov, Thord and Carlsson, Åke and Dahlberg, Leif},
  issn         = {1554-527X},
  keyword      = {collagen (NTx),bone turnover markers,osteolysis,total hip arthroplasty,cross-linked N-telopeptide of type I},
  language     = {eng},
  number       = {7},
  pages        = {1342--1348},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Orthopaedic Research},
  title        = {Cross-linked N-telopeptide of type I collagen (NTx) in urine as a predictor of periprosthetic osteolysis.},
  url          = {http://dx.doi.org/10.1002/jor.20152},
  volume       = {24},
  year         = {2006},
}