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Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation.

Gram, Magnus LU ; Sveinsdottir, Snjolaug LU ; Ruscher, Karsten LU ; Hansson, Stefan LU ; Cinthio, Magnus LU ; Åkerström, Bo LU and Ley, David LU (2013) In Journal of Neuroinflammation 10(Aug.,6).
Abstract
Cerebral intraventricular hemorrhage (IVH) is a major cause of severe neurodevelopmental impairment in preterm infants. To date, no therapy is available that prevents infants from developing serious neurological disability following IVH. Thus, to develop treatment strategies for IVH, it is essential to characterize the initial sequence of molecular events that leads to brain damage. In this study, we investigated extracellular hemoglobin (Hb) as a causal initiator of inflammation in preterm IVH.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
10
issue
Aug.,6
publisher
BioMed Central
external identifiers
  • wos:000322901900001
  • pmid:23915174
  • scopus:84881056966
ISSN
1742-2094
DOI
10.1186/1742-2094-10-100
language
English
LU publication?
yes
id
c0f3ef8d-c2c0-43d2-b724-8aac32be5349 (old id 4006172)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23915174?dopt=Abstract
date added to LUP
2013-09-03 13:57:26
date last changed
2019-02-20 05:52:54
@article{c0f3ef8d-c2c0-43d2-b724-8aac32be5349,
  abstract     = {Cerebral intraventricular hemorrhage (IVH) is a major cause of severe neurodevelopmental impairment in preterm infants. To date, no therapy is available that prevents infants from developing serious neurological disability following IVH. Thus, to develop treatment strategies for IVH, it is essential to characterize the initial sequence of molecular events that leads to brain damage. In this study, we investigated extracellular hemoglobin (Hb) as a causal initiator of inflammation in preterm IVH.},
  articleno    = {100},
  author       = {Gram, Magnus and Sveinsdottir, Snjolaug and Ruscher, Karsten and Hansson, Stefan and Cinthio, Magnus and Åkerström, Bo and Ley, David},
  issn         = {1742-2094},
  language     = {eng},
  number       = {Aug.,6},
  publisher    = {BioMed Central},
  series       = {Journal of Neuroinflammation},
  title        = {Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation.},
  url          = {http://dx.doi.org/10.1186/1742-2094-10-100},
  volume       = {10},
  year         = {2013},
}