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Fetal posterior cerebral artery configurations in an ischemic stroke versus an unselected hospital population

Frid, Petrea LU ; Wasselius, Johan LU ; Drake, Mattias LU ; Wu, Ona ; Petersson, Jesper LU ; Rost, Natalia S. and Lindgren, Arne LU (2022) In Acta Neurologica Scandinavica 145(3). p.297-304
Abstract

Background: Few MRA-based studies have systematically evaluated the prevalence and laterality of a fetal configuration of the posterior cerebral artery (FTP) in ischemic stroke populations versus other populations. This common variant is important in the setting of acute stroke and secondary prevention decisions. Objective: To determine the prevalence and laterality of FTP configurations in MRI-DWI verified acute ischemic stroke patients investigated with MRA, and compare the findings with an unselected hospital population investigated with computed tomography angiography (CTA). We also evaluated the association of FTP with posterior cerebral artery (PCA) territory infarctions. Methods: We reviewed the MRAs of 1407 ischemic stroke... (More)

Background: Few MRA-based studies have systematically evaluated the prevalence and laterality of a fetal configuration of the posterior cerebral artery (FTP) in ischemic stroke populations versus other populations. This common variant is important in the setting of acute stroke and secondary prevention decisions. Objective: To determine the prevalence and laterality of FTP configurations in MRI-DWI verified acute ischemic stroke patients investigated with MRA, and compare the findings with an unselected hospital population investigated with computed tomography angiography (CTA). We also evaluated the association of FTP with posterior cerebral artery (PCA) territory infarctions. Methods: We reviewed the MRAs of 1407 ischemic stroke patients with acute lesions on MRI-DWI sequences and 546 consecutive CTAs of patients investigated on any indication in a tertiary hospital. The MRA and CTA assessments were made by neuroradiologists blinded to original reports on stroke location and vessel anatomy. Results: The prevalence of any FTP was similar in ischemic stroke patients (31%) and unselected patients (32%). Unilateral FTP was significantly more frequent on the right than on the left side in both groups (15% right vs. 8% left). The presence of FTP ipsilateral to stroke side was not associated with involvement of the PCA territory versus no FTP on the stroke side. Conclusions: FTP is present in approximately 30% of ischemic stroke patients and unselected hospital populations and was detected significantly more frequently on the right versus left side in both groups. PCA territory infarction was not associated with the presence of ipsilateral FTP.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CTA, fetal type posterior cerebral artery, ischemic stroke, MRA
in
Acta Neurologica Scandinavica
volume
145
issue
3
pages
297 - 304
publisher
Wiley-Blackwell
external identifiers
  • scopus:85119656460
  • pmid:34811730
ISSN
0001-6314
DOI
10.1111/ane.13558
language
English
LU publication?
yes
id
c11eee74-2e7c-41b5-b54b-e1191ed535a8
date added to LUP
2021-12-10 12:26:45
date last changed
2024-06-15 22:30:06
@article{c11eee74-2e7c-41b5-b54b-e1191ed535a8,
  abstract     = {{<p>Background: Few MRA-based studies have systematically evaluated the prevalence and laterality of a fetal configuration of the posterior cerebral artery (FTP) in ischemic stroke populations versus other populations. This common variant is important in the setting of acute stroke and secondary prevention decisions. Objective: To determine the prevalence and laterality of FTP configurations in MRI-DWI verified acute ischemic stroke patients investigated with MRA, and compare the findings with an unselected hospital population investigated with computed tomography angiography (CTA). We also evaluated the association of FTP with posterior cerebral artery (PCA) territory infarctions. Methods: We reviewed the MRAs of 1407 ischemic stroke patients with acute lesions on MRI-DWI sequences and 546 consecutive CTAs of patients investigated on any indication in a tertiary hospital. The MRA and CTA assessments were made by neuroradiologists blinded to original reports on stroke location and vessel anatomy. Results: The prevalence of any FTP was similar in ischemic stroke patients (31%) and unselected patients (32%). Unilateral FTP was significantly more frequent on the right than on the left side in both groups (15% right vs. 8% left). The presence of FTP ipsilateral to stroke side was not associated with involvement of the PCA territory versus no FTP on the stroke side. Conclusions: FTP is present in approximately 30% of ischemic stroke patients and unselected hospital populations and was detected significantly more frequently on the right versus left side in both groups. PCA territory infarction was not associated with the presence of ipsilateral FTP.</p>}},
  author       = {{Frid, Petrea and Wasselius, Johan and Drake, Mattias and Wu, Ona and Petersson, Jesper and Rost, Natalia S. and Lindgren, Arne}},
  issn         = {{0001-6314}},
  keywords     = {{CTA; fetal type posterior cerebral artery; ischemic stroke; MRA}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{297--304}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{Fetal posterior cerebral artery configurations in an ischemic stroke versus an unselected hospital population}},
  url          = {{http://dx.doi.org/10.1111/ane.13558}},
  doi          = {{10.1111/ane.13558}},
  volume       = {{145}},
  year         = {{2022}},
}