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Assessment of MRI contrast agent concentration by quantitative susceptibility mapping (QSM) : application to estimation of cerebral blood volume during steady state

Lind, Emelie LU ; Knutsson, Linda LU orcid ; Kämpe, Robin ; Ståhlberg, Freddy LU and Wirestam, Ronnie LU orcid (2017) In Magnetic Resonance Materials in Physics, Biology, and Medicine 30(6). p.555-566
Abstract

Objective: One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. Materials and methods: A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test–retest study. By selecting a CSF reference region of interest (ROI), the values of all QSM images were shifted to show no CA-induced change in CSF. CA concentration and cerebral blood volume (CBV) were estimated using shifted QSM data. CSF reference ROI optimization was evaluated by... (More)

Objective: One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. Materials and methods: A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test–retest study. By selecting a CSF reference region of interest (ROI), the values of all QSM images were shifted to show no CA-induced change in CSF. CA concentration and cerebral blood volume (CBV) were estimated using shifted QSM data. CSF reference ROI optimization was evaluated by investigation of CBV repeatability. The CBV age dependence was analysed and tissue T2* relaxivity was estimated. Results: The best repeatability of CBV, using an optimal CSF reference ROI, showed test-versus-retest correlations of r = 0.81 and r = 0.91 for white and grey matter, respectively. A slight CBV decrease with age was observed, and the estimated in vivo T2* relaxivity was 85 mM−1s−1. Conclusion: Provided that a carefully selected CSF reference ROI is used to shift QSM image values, susceptibility information can be used to estimate concentration of contrast agent and to calculate CBV.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebral blood volume, Cerebrovascular circulation, Contrast agents, Magnetic resonance imaging, Magnetometry, QSM
in
Magnetic Resonance Materials in Physics, Biology, and Medicine
volume
30
issue
6
pages
555 - 566
publisher
Springer
external identifiers
  • scopus:85021165440
  • pmid:28631203
  • wos:000416258200005
ISSN
0968-5243
DOI
10.1007/s10334-017-0637-9
project
Optimisation and Validation of Dynamic Susceptibility Contrast MRI
language
English
LU publication?
yes
id
c4bfab36-3294-4414-932a-f95232daddfa
date added to LUP
2017-08-11 14:17:29
date last changed
2025-01-07 18:30:07
@article{c4bfab36-3294-4414-932a-f95232daddfa,
  abstract     = {{<p>Objective: One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. Materials and methods: A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test–retest study. By selecting a CSF reference region of interest (ROI), the values of all QSM images were shifted to show no CA-induced change in CSF. CA concentration and cerebral blood volume (CBV) were estimated using shifted QSM data. CSF reference ROI optimization was evaluated by investigation of CBV repeatability. The CBV age dependence was analysed and tissue T2* relaxivity was estimated. Results: The best repeatability of CBV, using an optimal CSF reference ROI, showed test-versus-retest correlations of r = 0.81 and r = 0.91 for white and grey matter, respectively. A slight CBV decrease with age was observed, and the estimated in vivo T2* relaxivity was 85 mM<sup>−1</sup>s<sup>−1</sup>. Conclusion: Provided that a carefully selected CSF reference ROI is used to shift QSM image values, susceptibility information can be used to estimate concentration of contrast agent and to calculate CBV.</p>}},
  author       = {{Lind, Emelie and Knutsson, Linda and Kämpe, Robin and Ståhlberg, Freddy and Wirestam, Ronnie}},
  issn         = {{0968-5243}},
  keywords     = {{Cerebral blood volume; Cerebrovascular circulation; Contrast agents; Magnetic resonance imaging; Magnetometry; QSM}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{555--566}},
  publisher    = {{Springer}},
  series       = {{Magnetic Resonance Materials in Physics, Biology, and Medicine}},
  title        = {{Assessment of MRI contrast agent concentration by quantitative susceptibility mapping (QSM) : application to estimation of cerebral blood volume during steady state}},
  url          = {{http://dx.doi.org/10.1007/s10334-017-0637-9}},
  doi          = {{10.1007/s10334-017-0637-9}},
  volume       = {{30}},
  year         = {{2017}},
}